Standard		HPLC		PAGE		In vivo		In vivo HPLC
		Purified		Purified				Purified
Desalted		Desalted		Desalted		Desalted		Desalted
Duplex		Duplexed		Duplexed		Duplexed		Duplexed
		Idea for modified RNA		Idea for modified RNA		Endotoxin tested		Endotoxin tested
						Na+ Salt Exchange		Na+ Salt Exchange
						Use for in vivo use		Idea for Modified siRNA
								Use for in vivo use
20 nmol	$250	20 nmol	$395	20 nmol	$395	25 nmol	$590	50 nmol	$870
40 nmol	$340	40 nmol	$545	40 nmol	$595	100 nmol	$650	100 nmol	$1070
150 nmol	$400	75 nmol	$600	80 nmol	$630	200 nmol	$850	250 nmol	$1420
300 nmol	$600	150 nmol	$800	150 nmol	$850	500 nmol	$1140	500 nmol	$2190
750 nmol	$800	375 nmol	$1075	320 nmol	$1130	1000 nmol	$1720	1250 nmol	$3320
1500 nmol	$1400	750 nmol	$1760			2500 nmol	$2570	2500 nmol	$4480
3750 nmol	$2250	1875 nmol	$2650			5000 nmol	$3780
7500 nmol	$3380	3750 nmol	$4080

Standard		HPLC		PAGE		In vivo		In vivo HPLC
		Purified		Purified				Purified
Desalted		Desalted		Desalted		Desalted		Desalted
Duplex		Duplexed		Duplexed		Duplexed		Duplexed
		Idea for modified RNA		Idea for modified RNA		Endotoxin tested		Endotoxin tested
						Na+ Salt Exchange		Na+ Salt Exchange
						Use for in vivo use		Idea for Modified siRNA
								Use for in vivo use
20 nmol	$395	20 nmol	$500	15 nmol	$500	25 nmol	$750	50 nmol	$1118
40 nmol	$440	40 nmol	$700	30 nmol	$760	100 nmol	$835	100 nmol	$1375
150 nmol	$510	75 nmol	$770	65 nmol	$810	200 nmol	$1090	250 nmol	$1825
300 nmol	$775	150 nmol	$1028	120 nmol	$1090	500 nmol	$1465	500 nmol	$2815
750 nmol	$1025	375 nmol	$1380	290 nmol	$1452	1000 nmol	$2210	1250 nmol	$4268
1500 nmol	$1800	750 nmol	$2260			2500 nmol	$3300	2500 nmol	$5700
3750 nmol	$2890	1875 nmol	$3400			5000 nmol	$4860
7500 nmol	$4345	3750 nmol	$4270

• Desalted Single-Stranded:

• Desalted Duplex:

• HPLC purified: *Special Note: The siRNA duplex is now dried down in the absence of buffer and the amount packaged per tube has changed, however, the total amount of material supplied remains the same.

• siRNA In-Vivo-Ready:A minimum of 90% purity. These duplexes are shipped in the deprotected form with extra processing also including counter ion (Na+) exchange, dialysis, sterile filtration and endotoxin testing for the introduction of siRNAs into animals.
  
  The estimated ship date is 10 business days for orders received before 3:00pm CST. Ship date will be confirmed upon order placement.

• HPLC purified: This In-Vivo-Ready custom synthesized siRNAs provide the highest quality siRNAs available anywhere ith guaranteed purity of 97%. The processing of the oligos includes extra level of HPLC purification, counter ion (Na+) exchange, dialysis to remove salt (to <1 microsiemens conductance at 50 µM siRNA), sterile filtration and endotoxin tested.
  
  The estimated ship date is 20 business days for orders received before 3:00pm CST. Ship date will be confirmed upon order placement.
  
  

Standard QC package

Analytical anion-exchange HPLC of oligonucleotide; purity guaranteed above 85% in case purification is required. TOF/MS for oligonucleotide identification.

Advanced QC package

Standard QC package and additionally:

Ion-pair reverse phase HPLC of the oligonucleotide at 60^oC, purity guaranteed above 85% analytical reverse phase HPLC Endotoxin analysis of the oligonucleotide (*phosphorothioates may inhibit in the mechanism for endotoxin determinations Bio- Synthesis is using and therefore reading might be less accurate for these molecules) pH determination of a 1% oligonucleotide solution.

Custom QC Package: Custom QC package such as:

Determination of the sodium content of the oligonucleotide (minimum 20 mg of purified oligonucleotide is required). LC-MS of the oligonucleotides. Any custom quality control methods could be developed. Our technical service staffs are willing to respond to your various advices and requests.