BIO-SYNTHESIS
provides various ways of customized your cyclic peptide.
Call 800-227-0627 or write
to us atbiosyn@biosyn.com
for more information on our peptide synthesis and cyclization.
Cyclization of pepitdes has been shown to be a usefull
approach in developing useful peptidic and peptidomimetic
agents for diagnostic and therapeutic research.
Since the structure of a peptide is determined by
its sequence and the chemical environmnet in which
it is placed, while the linear peptides are relatively
unrestrained and are able to adopt a range of conformations
that are not always ideal for some applications,
cyclic peptide reduces the conformational freedom
than of these flexible, linear molecules, and often
results in higher receptor binding affinities by
reducing unfavorable entropic effects1. Two strategies
of cyclization used in our laboratory 1) Backbone
to backbone cyclization strategies by the formation
of the amide bond between the N-terminal and C-terminal
amino acid residues, and 2) Cyclization of side
chain amino acid such as:
Formation
of disulfide bridges between cysteine, (homocycsteine)
The formation
of lactam bridges between glutamic/aspartic acid
and lysine residues
The formation
of lactone and thiolactone bridges between amino
acid containing carboxyl, hydroxyl or mercapto functional
groups.
The formation
of thioether or ether bridges between the amino
acids containing hycroxyl or mercapto functional
groups and other special methods.
All our peptide synthesis
and cyclization services includes:
Design and
synthesis consultation
HPLC analysis
for peptide purity
Mass Spectrometry
Analysis for peptide identification
# Additional
services includes: amino acid analysis and sequencing.
Call 800-227-6027
or for price quote on peptide cyclization, click here
