Enhanced Diagnostic Tools
There are many benefits of using plain and mixed oligonucleotide dendrimers. Applications
based on the use of oligo dendrimers are derived from the high density and the large
number of groups on the periphery. Dendrimers with a positively charged surface
interact strongly with nucleic acids, helping to transport them through the membranes
of cells2; dendrimers with internal cavities interact non-covalently
with guest molecules to give guest-host systems3. Dendrimeric oligonucleotides4
have been used to amplify radioactive or fluorescent signals in the non-radioactive
assays, where signal is limited by the surface density of the oligonucleotides or
the target molecule.
Bio-Synthesis provides plain or mixed oligonucleotide dendrimers using a set of
branching modifier consist of symmetric, asymmetric doublers
and symmetric trebler. that allow dendritic oligonucleotide
to be constructed from interconnected synthetic monomeric subunits which open ways
to 2D or 3D structures.
Inquire for Custom Oligonucleotide Dendrimer Synthesis.
Two strategies for the synthesis of oligonucleotide dendrimers are possible: Divergent
- with the structure growing from the center to the periphery; and Convergent -
with growth from the periphery to the center. The number of branches generated at
each step determines the number of repetitive steps necessary to build up the desired
molecule and the density of groups at the periphery. The groups or moieties on its
outer shell determine the properties of the molecule. The dendrimeric modifiers
we use permit the synthesis of a dendrimeric structure on top of a conventional
monomeric oligonculeotide, as well as directly on the solid support at 3' end. The
monomeric and the dendrimeric sequence segments can be prepared with different lengths
and different orientation by using 3' or 5' oligonucleotide synthesis chemistry.
Due to complexity of the construct, please contact us
The symmetric doubler produces branches with the same oligo sequence.
The symmetric doubler produces branches with the same oligo sequence
Different generations of dendrimeric oligonucleotides