Enhanced Diagnostic Tools
Scientific interest in the study of epigenetic pathways that regulate gene expression without changing the genomic DNA has grown into one of the most exciting and dynamic fields in biology and cancer research. Post translational modifications such as DNA methylation, histone modification, as well as small regulatory RNAs are the hallmark of these epigenetic events. Of those, DNA methylation is the best recognized modification found in CpG sequence motifs. 5-methylcytosine (5mC) is a well-known epigenetic marker which regulates transcription of the genome. Since 2009 several modified TET-enzyme generated nucleobases such as 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) have been detected in the mammalian genome and were recently found to be key players in epigenetic pathways.
Bio-Synthesis offers several modified RNA and DNA oligos for epigenetic cancer research. We are one of the few manufacturers which offer the newly discovered and difficult to synthesize epigenetically modified bases such as N4-Me-dC, N4-Me-rC, N1-Me-dA, N2-Me-dG. In addition, we also offer many nucleoside triphosphates which can be incorporated into long RNAs either enzymatically or chemically.
Please contact us more information and for assistance in finding your desired modification.