Zip Nucleic Acids (ZNA®), oligospermine-oligonucleotide conjuugates. These conjugates are believed to use the oligospermine to seek out and move along (scan) oligonucleotide strands until the probe complementary sequence is located. The oligospermine then performs the function of stabilizing the formed duplex by reducing electrostatic repulsion, thereby leading to significantly increased binding affinities. Oligo synthesis can be added multiple times at the 3' or 5' terminus.
ZNA® Oligos have found use in the following applications:
- Multiplex PCR
- PCR of AT-rich Regions
- RT qPCR
- Detection of MicroRNA
- Improved SNP Discrimination
- Antisense and Antigene Effects
The intellectual property of Polyplus-transfection SA. ZNA® is a registered trademark of Polyplus-transfection SA.
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