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Can I use IQ Quencher as BHQ replacement?

Yes, IQ4 can be use to replace BHQ1,2,3 this fourth generation of Instant Quenchers™, IQ4™, has unique fluorescence quenching properties with an operational range between 500 nm and 700 nm and can therefore be utilized in multiplexed assays pairing IQ-4 quencher dye with different fluorophores.