Contact Us
800.227.0627

cell Penetrating Peptide DNA Synthesis and Conjugation

Does BSI provide cell penetrating peptide DNA Synthesis?

Yes, BSI provides DNA and cell penetrating peptide synthesis as well as conjugation services. These positively charged cell penetrating peptide can be conjugated to DNA or RNA oligonucleotides at our laboratory.

The cell penetrating sequences can be used as an extension to an existing peptide sequence to make them more permeable to cell membranes, or when conjugated to DNA or RNA, make these oligonucleotide more permeaable to cell.

Examples are the HIV-TAT sequence which composed of GRKKRRQRRRPQ can be design as part of a peptide sequence of interest. This cell penetrating peptide is most commonly used and one of the many options for making peptides more permeable to cells.

Other example of cell penetrating peptide are:

  • ac-GALFLGFLGAAGSTMGAWSQPKKKRKV-cys,
  • ac-GALFLGFLGAA-GSTMGAWSQPKSKRKV-cys,
  • RRRRRRRR, or
  • LIKLWSHLIHIWFQNRRLKWKKK.
Alternatively, the N-terminal end of a peptide can be modified with myristic acid (also called tetradecanoic acid). This hydrophobic functional group acts as a lipid anchor in phopholipid bilayers.

Contact us for cell penetrating peptide bioconjugation services.