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Coupling agent or cross linker elicit immuno response?

Yes, most people do not realize antibodies can be generated to the cross linker used to link the peptide to a carrier protein. It is therefore advisable to prepare two conjugates of the same peptide with different carrier proteins and different coupling method when placing order.

Useful Reading:

"The generation of antibodies to the couplig agent used for the peptide conjugation"

"Immunogenicity of new heterobifunctional cross-linking reagents used in teh conjugation of synthetic peptides to liposomes"