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Aldehyde Modified Oligo

Does Bio-Synthesis Offers Aldehyde Modified Oligo?

Bio-Synthesis offers aldehyde modified oligonucleotides. Oligonucleotides modified with aldehyde groups (RCHO) contain a reactive carbonyl group which can react readily with primary amines. Since primary amines are abundant in protein amino acid side chains, aldehyde modified oligonucleotides are often used to conjugate oligos to proteins such as antibodies. However, natural occuring primary amines present in proteins are not strongly or permanently reactive with aldehdyes, except in certain conditions when additional compounds are added to stabilize the bond. Instead, hydrazides and alkoxyamines can be used to activate primary amines in proteins allowing the reaction with aldehyde modified oligonucleotide. The terminal amino groups in these compounds are more strongly nucleophilic than protein amines and can spontaneously react with aldehydes to form stable bonds.

Bio-Synthesis can incorporate aldehyde groups to oligonucleotides at 5'- and 3'-terminal ends or internally at various scales and purity. Contact Bio-Synthesis for  Aldhyde Modified Oligo Synthesis Services.

Structure below are two types of 5' aldehyde modification:

5' Aldehyde modified oligo