Enhanced Diagnostic Tools
Using a new synthesis technology, Bio-Synthesis is able to meet our customer requirements for high quality RNA and RNA analogs such as BNA oligonucleotide from mg to multi-gram quantity for pre-clinical, diagnostic or therapeutic studies. At Bio-Synthesis, DNA, RNA, BNA, LNA and other RNA analogs. These oligo can be synthesized at mid-scale range from mg to multi-gram quantity and maintaining our quality commitment. All products are analyzed by PAGE, HPLC and mass spectroscopy. Turn around time varies based on sequence, purification and quantity requested. It is always advisable to order your material well in advance to ensure that you receive the material prior to establishing your studies.
Use of the dedicated equipment for large-scale synthesis enables synthesis of gram quantity oligonucleotide (under 25 mers) per one lot. All the products have their original lot numbers and are under the strict lot control.
Salt content is as important as purity in large-scale synthesis. This is the reason for setting RP-Cartridge and desalting as a default purification method for this service.
Bio-synthesis's In Vivo-Ready purification option provides high quality oligos that are ready for introduction into animals. Each oligo is HPLC purified, dialyzed to ensure that the oligonucleotide is salt free (conductance of <1 microsiemens for a 50 µM solution), sterile filtered, and endotoxin tested. Of course, all oligonucleotides are been analyzed by MALDI-TOF mass spectrometry and analytical HPLC, and sequencing.
All synthesized DNA are subject to quality control by polyacrylamide gel electrophoresis. For the products under 35mer, any small deletion will be found by MALDI-TOF/MS spectrometry analysis system. RP-HPLC purification analysis is also applied for the purpose of complete QC.
We were among the first to adapt quality control by TOF/MS. Such experience enables us to offer some optional services such as primer sequencing (the direct analysis of primer sequence), or purity analysis data attachment by RP-HPLC or IEX-HPLC.
Our technical service staffs are willing to respond to your various advices and requests.
Reliable products can be provided by synthesizing in the manufacturing line compliant with GMP (Good Manufacturing Practice). We will support your R&D with stable clean quality.
Prices are for unmodified oligonucleotides between 15 and 25 bases. It includes purification and ethanol precipitation. Please request a quotation for other lengths or larger quantities. The backbone may consist of phosphorothioate or phosphodiester linkages, or a combination of the two. Prices may vary due to sequence composition.
Please submit your order or quotation request to the Client Relations department via e-mail, fax (972) 420-0442, or you can use our online ordering system
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