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DOTA-Peptide Radio Metal Labeling

Does Bio-Synthesis Provide DOTA-Peptide Radio Metal Labeling?

Yes, Bio-Synthesis offer DOTA-Peptide synthesis and labeling services at various scales and purity. DOTA is the most frequenctly used chelating agent for radio-metal labeling of peptides.  This cyclic chelator 1,4,7,10-tetrazacyclododecane-N,N',N'',N''' -tetraacetic acid (DOTA) contains 4 amino groups and 4 carboxylic groups for coordination of metals, the carboxylic group can be utilized for attachment to amino groups of peptides.

DOTA-Peptide Conjugates

Preparation of peptide-DOTA conjugates can be achieved either by specifically protected building blocks during the peptide synthesis or  via activated esters after the peptide has been prepared. Please provide us peptide sequence and final deliver amount for peptide-DOTA conjugation services.