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LNA Phosphorothioate Bonds

How to place my LNA order

Several method to place LNA order

Example of an LNA order:

5' G*C*C*T*G*C*G*A*T*A*T*G*T*C*C*A*T*C*T*G 3' DNA, All PS
5' C*T*C*TGCCTATAGTCCAT*C*T*G 3' DNA, PS/PO chimera
5' mU*mG*mC*mU*mG*G*G*T*A*A*T*G*A*C*G*mA*mU*mC*mC*mU 3' 2'-O-Me/DNA chimera, All PS
5' mU*mG*mC*mU*mG*rG*rG*rT*rA*rA*rA*rG*rA*rC*rG*mA*mU*mC*mG*mU 3' 2'-O-Me/RNA chimera, All PS
5' +C+T+C+T+GC*G*A*A*A*T*C*A*C*C+A+T+G+C+T/3Phos/3' LNA/DNA chimera, PS/PO chimera, 3'-phos
*=Phosphorothioate Bonds
mN=2'-O-Me RNA base
+N=LNA base
rN=RNA base
 
Example of a LNA/DNA with PS and PO Chimera Linkages (Phosphorothioate and Phosphodiester) with 3'-phosphate
5' +T+A+T+T+GC*G*A*G*A*T*G*T*C*C+A+T+C+C+T/3Phos/3'