For short-term storage, resuspended RNA should be stored at -20°C; for long-term storage, it should be stored at -80°C. Although RNA resuspended in water or buffer can be stored at -80°C, RNA is most stable in an NH4OAc/ethanol precipitation mixture at -80°C. We recommend aliquoting RNA solutions into several tubes. This will both prevent damage to the RNA from successive freeze-thaw events, and help to prevent accidental RNase contamination. Finally the best long-term storage, RNA oligos should be dried.