Enhanced Diagnostic Tools
LNA may be used to enhance:
LNA should be used in any hybridisation assay, which requires high specificity and/or reproducibility.
The LNA modification suits perfectly to SNP detection.
This modification increases the specificity of the probe but also its power of discrimination.
LNA exhibits the same salt dependence as DNA and RNA.
Tm increase/monomer against DNA (°C)
2.0 - 6.0
Tm increase/monomer against RNA (°C)
3.0 - 8.0
DTm at single mismatch against DNA
LNA >> DNA
Compatible with standard oligo synthesis
Chimera with DNA
Compatible with standard molecular biology
Works in PCR primers
Enhances allele specific priming
Hybridization performance is predictable
Homogenous assay performance
LNA >> RNA
If you have a query regarding any of our products or services,
please don't hesitate to submit your question below. A member of our support team
will review and answer your question as quickly as possible.