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PCR Blocker

Can you use BNA as PCR Blocker?

Yes, Bridged Nucleci Acids, BNA oligo can be used as a sequence specific PCR blocker because BNA probe has stong binding affintiy and specificity to its target DNA. Spiking oligonucleotide with BNA or BNA clamping is an efficient way to correct amplification bias and sequencing errors. Bio-Synthesis also provide BNA clamping development service to our customer seeking SNP specific genotyping for mutant screening. Contact Bio-Synthesis for PCR Blocker Synthesis or development services.