Why use Special Amino Acids in peptide synthesis?
Unnatural amino acids result in peptidomimetics that may increase in‐vivo half life and potency. d‐Amino acids are often used instead of natural l‐amino acids to increase peptide stability against proteases. Replacing the N‐H of the amide backbone with N‐Methyl is useful for destabilising the formation of secondary structure and preventing peptide aggregation.
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05/08/2013