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What are the advantages of using BNA probes?

Bridged Nucleic Acid BNA modified oligonucleotide provides several advantages including but not limit to :
  • Improved hybridization selectivity and specificity over PNA & LNA
  • Ideal for the detection of short RNA and DNA targets
  • Facilitate Tm normalization
  • Increased thermal duplex stability of duplexes
  • Increased thermal stability of triplexes
  • Capable of single nucleotide discrimination
  • Resistance to exo- and endonucleases resulting in high biological stability for in vivo and in vitro application
  • Superior antisense inhibition and potency
  • Strand invasion enable detection of "hard to access" sample
  • Flexible probe designs regardless of GC content
  • Easily adaptable to many DNA or RNA detection system