What are the advantages of using BNA probes?
Bridged Nucleic Acid BNA modified oligonucleotide provides several advantages including but not limit to :
- Improved hybridization selectivity and specificity over PNA & LNA
- Ideal for the detection of short RNA and DNA targets
- Facilitate Tm normalization
- Increased thermal duplex stability of duplexes
- Increased thermal stability of triplexes
- Capable of single nucleotide discrimination
- Resistance to exo- and endonucleases resulting in high biological stability for in vivo and in vitro application
- Superior antisense inhibition and potency
- Strand invasion enable detection of "hard to access" sample
- Flexible probe designs regardless of GC content
- Easily adaptable to many DNA or RNA detection system
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08/06/2013