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When should I use LNA™?

LNA™ oligonucleotides can be used with great advantage in any application where high hybridization specificity is needed, and in particular when the target sequence is relatively short. The high binding affinity of LNA™ allows for the use of short and very specific probes in e.g.

  • Hybridization probes for the detection of nucleic acids and genotyping
  • Padlock probes, modified Taqman™ probes and probes for in situ hybridization
  • Capture probes for target enrichment, sample preparation and affinity chromatography
  • Allele-specific PCR1
  • Antisense oligonucleotide technology
  • Oligonucleotides for therapeutic or diagnostic applications, such as, aptamers, ribozymes, decoy oligonucleotides and siRNA
  • PCR-based applications