 |
| Bio-Synthesis continued to provide quality DNA products and services for the research community, but it has also become a world leader in providing custom peptide products and services. We offer comprenhensive services for polyclonal antibody production with large selection fo host animals. Each of our facilities is operated under USDA license and hold an NIH Animal Welfare Assurance from the Office of Laboratory Animal Welfare. |
|
|
|
| |
 |
|
Locked Nucleic Acid |
|
| |
A locked nucleic acid (LNA), often referred to as inaccessible RNA, is a modified RNA nucleotide. The ribose moiety of an LNA nucleotide is modified with an extra bridge connecting the 2' and 4' carbons. The bridge "locks" the ribose in the 3'-endo structural conformation, which is often found in the A-form of DNA or RNA. |
|
|
|
|
| |
 |
|
Oligonucleotide |
|
| |
Oligonucleotides are short sequences of nucleotides (RNA or DNA), typically with twenty or fewer bases. Automated synthesizers allow the synthesis of oligonucleotides up to 160 to 200 bases. |
|
|
|
|
| |
 |
|
Antisense Oligonucleotides |
|
| |
Antisense oligonucleotides are single strands of DNA or RNA that are complementary to a chosen sequence. In the case of antisense RNA they prevent translation of complementary RNA strands by binding to it. Antisense DNA can be used to target a specific, complementary (coding or non-coding) RNA. If binding takes places this DNA/RNA hybrid can be degraded by the enzyme RNase H. |
|
|
|
|
| |
|
|
