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| Bio-Synthesis continued to provide quality DNA products and services for the research community, but it has also become a world leader in providing custom peptide products and services. Using state-of-the-art solid phase peptide chemistries,Biosynthesisr-based PNA FISH tests that provide rapid identification of bloodstream pathogens in hours instead of days, enabling labs to quickly report critical information to physicians and pharmacists to ensure optimal therapy and help reduce death rates for patients afflicted with bloodstream infections. |
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Antisense Oligonucleotides |
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Antisense oligonucleotides are promising therapeutical agents for numerous diseases resulting from overexpression of genes, expression of mutant genes and viral infections. As most oligonucleotides are polyanions they can not readily pass cellular membranes in adequate amounts to show activity. Therefore, different types of carrier systems and modifications have been developed to enhance absorption and distribution at the level of tissues and cells. |
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Antisense Phosphorothioate Oligonucleotide |
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A guiding principle in pharmacology is that there should be a correlation between dose and pharmacologic activity of a therapeutic agent. At times it is not always possible to define such relationships because of poor absorption, first-pass effects, elimination, or any one of a multitude of factors. metabolic factors. |
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Antisense Therapeutic |
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Antisense oligonucleotides (ASO) against specific Biosynthesisr targets (e.g., Bcl-2 and Raf-1) are important reagents in cancer biology and therapy. Phosphorothioate modification of the ASO backbone has resulted in an increased stability of ASO in vivo without compromising, in general, their target selectivity. |
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