Emergence of Smooth Muscle Cell Endothelin B–Mediated Vasoconstriction in Lambs With Experimental Congenital Heart Disease and Increased Pulmonary Blo
Stephen M. Black, Eugenia Mata-Greenwood, Robert W. Dettman, Boaz Ovadia, Robert K. Fitzgerald, Olaf Reinhartz, Stefan Thelitz, Robin H. Steinhorn, Rene Gerrets, Karen Hendricks-Munoz, Gregory A. Ross
05/22/2014
Endothelin-1 (ET-1) has been implicated in the pathophysiology of pulmonary hypertension. In 1-monthold lambs with increased pulmonary blood flow, we have demonstrated early alterations in the ET-1 cascade. The objective of this study was to investigate the role of potential later alterations of the ET cascade in the pathophysiology of pulmonary hypertension secondary to increased pulmonary blood flow.