| Product |
5' |
Internal |
3' |
Function |
| Abasic |
Y |
Y |
Y |
dSpacer (abasic furan) is a tetrahydrofuran base, used to facilitate the determination of DNA structure by X-ray crystallography |
| Acridine |
Y |
Y |
N |
Acridine modified oligo are been used as an intercalating agent to target dsDNA and add stability to double helix. |
| Azobenzene |
Y |
Y |
Y |
Switch between cis and trans conformations an upon irradiation with UV or visible light for photo-control applications |
| Biotin |
Y |
Y |
Y |
Biotin-modified oligos bind tightly to streptavidin. The streptavidin can be labeled with fluorescent dyes and enzymes or mediate attachment to a solid surface to be used in a variety of molecular biology assays and purification methods. |
| Biotin Diol Linker |
Y |
Y |
Y |
Biotin contains a cleavable diol linker that can be used for detection, cleaved proteins that are not visible by means of streptavidine blot. |
| Biotin TEG |
Y |
Y |
Y |
Biotin-TEG a 15 atom mixed polarity triethylene glycol spacer which acts to minimize steric hindrance between biotin and the oligo, thereby providing streptavidin easy access to the biotin for capture and immobilization of the oligo. |
| dT-Biotin |
Y |
Y |
Y |
The internal version of this modification is attached to the oligo through a dT base. Incorporation of the internal version will add a dT nucleotide at that position. |
| Dual Biotin |
Y |
N |
N |
Two biotins are sequentially placed on the 5’-end, which increases the efficiency of streptavidin binding. |
| PC Biotin |
Y |
Y |
Y |
Photocleavable Biotin with optimal cleavage is obtained when exposure to long-wave UV light in the 300-350 nm spectral range. Cleavage releases the oligo with a 5’-phosphate group. |
| Cholesteryl TEG |
Y |
Y |
Y |
A photo reactive halogenated base, used to facilities the determination of DNA structure by X-ray crystallography |
| Desthiobiotin TEG |
Y |
Y |
Y |
Desthiobiotin, a biotin analog with affinity toward streptavidin biotin. Displacement of Desthiobiotin to streptavidin can occur by simply adding biotin to a reaction mixture. |
| DNP-TEG |
Y |
Y |
Y |
DNP with long triethylene glycol (TEG) spacer, commonly used to label oligonucleotides probes for use in hybridization applications |
| DNP-X |
Y |
Y |
Y |
DNP, a small molecule hapten having high immunogenicity |
| DOTA |
Y |
Y |
Y |
DOTA acts as a chelating agent and also possess a reactive site for covalent attachment to bio-targeting vectors such as antibodies, peptides and proteins. DOTA is widely used in nuclear medicine, MRI and optical imaging applications. |
| Psoralen C2 |
Y |
Y |
Y |
Psoralen is capable of intercalating between bases, and cross-link bases in both double-stranded and triple-stranded DNA |
| Psoralen C6 |
Y |
Y |
Y |
Psoralen is capable of intercalating between bases, and cross-link bases in both double-stranded and triple-stranded DNA |