8-Oxo-2'-deoxyguanosine Oligonucleotide Modification
8-oxo-dG can be incorporate into oligonucleotide at any position during synthesis. This modified base are often use for DNA damage and repair studies. When cellular DNA is constantly being damaged by oxidation and alkylation, by free radicals, and by ultraviolet and ionizing radiation. The body has therefore evolved a number of repair enzyme systems to excise and repair these lesions. The 8-oxo purine monomers allow investigation of the structure and activity of oligonucleotides containing an 8-oxo mutation which is formed naturally when DNA is subjected to oxidative conditions or ionizing radiation. 5,6-Dihydro pyrimidines are naturally occurring compounds that are structural components of alanine transfer RNA.
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Product Information
8-Oxo-2'-deoxyguanosine Oligonucleotide Modification
Modified Bases, Stuctural Studies, DNA damage and repair
-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.
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