8-Amino-2'-deoxyadenosine, 8-Amino-dA
8-Amino dA and 8-amino-dG, are 8-amino-puridines that are often used in the study of triplex (triple helix) formation due to the presence of an additional amino group. The 8-amino group is able to form an additional Hoogsteen purine-pyrimidine hydrogen bond, which serves to increase triple helix stability. Studies have shown that triple-helix-forming oligos (TFO) containing 8-amino-dA form stable helices at a neutral pH, instead of under acidic conditions.
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Product Information
8-Amino-2'-deoxyadenosine, 8-Amino-dA
-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.
References/Citations:
- Cubero, E., Avino, A., de la Torre, B.G., Frieden, M., Eritja, R., Luque, F.J., Gonzalez, C., Orozco, M. Hoogsteen-based parallel-stranded duplexes of DNA. The effect of 8-amino derivatives. J. Am. Chem. Soc. (2002), 124: 3133-3142.
- Zhu, Q., Delaney, M.O., Greenberg, M.M. Observation and elimination of N-acetylation of oligonucleotides prepared using fast-protecting phosphoramidites and ultra-mild deprotection. Bioorg. Med. Chem. Lett. (2001), 11: 11105-1107. - 8-amino-dA
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