EDTA 2'-Deoxyuridine Oligonucleotide Modification
Bio-Synthesis offers EDTA-C2-dT oligonucleotide midification. EDTA-C2-dT, also known as 5-(C2-EDTA)-2'-deoxyuridine, is a deoxythymidine conjugated with the triethanoic (that is, triacetic) acid derivative of EDTA at the C-5 position of the thymine base. Oligonucleotides containing EDTA-C2-dT are typically used as artificial nucleases for cleaving both single and double-stranded DNA1,2. The modified oligo serves as a molecular recognition moiety, while the EDTA complexed to a metal ion (such as Fe(II)) acts as the actual cleavage agent. This analytical approach has been used to investigate the tertiary structure of tRNA3 in experimetns requiring in vivo imaging such as PET.
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Product Information
EDTA 2'-Deoxyuridine Oligonucleotide Modification
5-(C2-EDTA)-2'-deoxyuridine, EDTA-dU
-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.
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