Contact Us
800.227.0627

Acridine Modified Oligonucleotide

Bio-Synthesis offer acridine oligonucleotide modification services. Acridine is an effective intercalating agent as well as being a lipophilic carrier molecule. Study have soen acridine can effectively stabilize heteroduplexes and inhibit gene expression1-3. Oligos containing acridine cannot be HPLC purified, nor can they be analyzed by HPLC, as they bind irreversibly to the column. Acridine is available as both a 3' and a 5' modifier. 

Contact us for Acridine Orange fluorescent dye oligonucleotide labeling services.

Product Information

 

Product Name:
Acridine Modified Oligonucleotide

Category:

Fluorescent dye Label, Intercalators

Modification Code:
[Acridine]

Chemical Formula:
C21H24CIN2O5P

Exact Mass:
458.86

Formula Weight:
450.86

Excitation (nm):
362

Emission (nm):
462

Extinction Coefficient, ε(λ):
11000

Structure:
Bio-Synthesis Inc. Oligo Structure

Purification:
HPLC

Delivery Format:
Lyophilized

Shipping Conditions:
Room Temperature

Storage Conditions:

-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.


References/Citations:

1. Asseline, U.; Delarue, M.; Lancelot, G.; Toulme, F.; Thuong, N. T.; Montenay-Garestier, T.; Helene, C. Proc. Natl. Acad. Sci. USA, 1984, 3297.
2. Thuong, N. T.; Asseline, U.; Roig, V.; Takasugi, M.; Helene, C. Proc. Natl. Acad. Sci. USA, 1987, 84, 5129.
3. Sun, J. S.; Asseline, U.; Rouzaud, D.; Montenay-Garestier, T.; Helene, C. Nucleic Acids Res., 1987, 15, 6149.

Technical Resources

Technical & Educational
Articles
Frequently
Asked Questions
Scientific
Literature
Scientific Apps
and Calculators