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3A-Amino-2A,4A-BNA: novel bridged nucleic acids having an N3A?P5A phosphoramidate linkage

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3A-Amino-2A,4A-BNA: novel bridged nucleic acids having an N3A?P5A phosphoramidate linkage

Novel oligonucleotide analogues, containing a 3A-amino-2A,4A-BNA unit, were successfully synthesized, and they showed superior duplex and triplex forming ability as well as BNA itself, along with remarkable enzymatic stability.

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3A-Amino-2A,4A-BNA: novel bridged nucleic acids having an N3A?P5A phosphoramidate linkage

3A-Amino-2A,4A-BNA: novel bridged nucleic acids having an N3A?P5A phosphoramidate linkage

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