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Disease dependent differentially expressed miRNAs

Disease dependent differentially expressed miRNAs

 

MicroRNAs (miRNAs) are known to play important roles in diseases pathology such as infections and cancer. The recent development of high-throughput technologies for the global measurement of miRNAs these molecules have now emerged as a new class of cancer biomarkers. Already many studies have explored associations between miRNAs and different cancer features. Often real-time polymerase chain (rt-PCR) reaction is used to measure the expression of miRNAs in various tissues. Analyzing global miRNA gene expression using complementary DNA microarrays allows for the examination of differentially expressed miRNAs. This type of assays allows finding disease specific miRNA associations which hopefully will reveal how miRNAs regulate their target genes. For example, miRNA profiling of different cancer tissue has the potential to allow determination of lineage and differentiation state of tumors. The following table contains a list of differentially regulated miRNAs in various diseases.


miRNAs

Disease Types

Up/Down-regulated

Reference

let-7a, let-7b, let-7c, let-7d, let-7g, miR-16, miR-23a, miR-23b, miR-26a, miR-92, miR-99a, miR-103, miR-125a, miR-125b, miR-143, miR-145, miR-195, miR-199a, miR-199a, miR-221, miR-222, miR-497

prostate cancer

down-regulated

Porkka KP, Pfeiffer MJ, Waltering KK, Vessella RL, Tammela TL, Visakorpi T: MicroRNA expression profiling in prostate cancer. Cancer Res 2007, Jul 1; 67(13):6130-5.

http://cancerres.aacrjournals.org/content/67/13/6130.abstract

 

miR-202, miR-210, miR-296, miR-320, miR-370, miR-373, miR-498, miR-503

prostate cancer

up-regulated

Porkka KP, Pfeiffer MJ, Waltering KK, Vessella RL, Tammela TL, Visakorpi T: MicroRNA expression profiling in prostate cancer. Cancer Res 2007, Jul 1; 67(13):6130-5.       

miR-16, miR-92a, miR-103, miR-107, miR-197, miR-34b, miR-328, miR-485-3p, miR-486-5p, miR-92b, miR-574-3p, miR-636, miR-640, miR-766, miR-885-5p

prostate cancer

up-regulated

Lodes MJ, Caraballo M, Suciu D, Munro S, Kumar A, Anderson B: Detection of cancer with serum miRNAs on an oligonucleotide microarray. PLoS One 2009, Jul 14; 4 (7):e6229. Published: July 14, 2009.

 

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006229

 

miR-21, miR-155, miR-221

Pancreatic cancer

up-regulated

Bloomston M, Frankel WL, Petrocca F, Volinia S, Alder H, Hagan JP, Liu CG, Bhatt D, Taccioli C, Croce CM: MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis JAMA 2007, 297(17):1901-1908. (doi:10.1001/jama.297.17.1901). http://www.ncbi.nlm.nih.gov/pubmed/17473300

 

miR-155, miR-21

colon, lung, breast,stomach, prostate

up-regulated

Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri A, Musiani P, Volinia S, Nenci I, Calin GA, Querzzoli P: MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005, 65:7065–7070. http://www.ncbi.nlm.nih.gov/pubmed/16103053

 

Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, Prueitt RL, Yanaihara N, Lanza G, Scarpa A, Vecchione A, Negrini M, Harris CC, Croce CM: A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 2006, Feb 14; 103(7):2257-2261. Epub 2006 Feb 3.

http://www.ncbi.nlm.nih.gov/pubmed/16461460

 

miR-142-5p, miR-369-3p, miR-215

lung cancer

up-regulated

Baffa R, Fassan M, Volinia S, O'Hara B, Liu CG, Palazzo JP, Gardiman M, Rugge M, Gomella LG, Croce CM, Rosenberg A: MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. J Pathol 2009, Jun 1.

http://www.ncbi.nlm.nih.gov/pubmed/19593777.

 

miR-373

lung cancer

down- regulated

Baffa et al. 2009

miR-30d, miR-125b, miR-26a, miR-30a-5p

 

thyroid anaplastic carcinomas

down- regulated

Visone R, Pallante P, Vecchione A, Cirombella R, Ferracin M, Ferraro A, Volinia S, Coluzzi S, Leone V, Borbone E, Liu CG, Petrocca F, Troncone G, Calin GA, Scarpa A, Colato C, Tallini G, Santoro M, Croce CM, Fusco A: Specific microRNAs are down regulated in human thyroid anaplastic carcinomas. Oncogene 2007, Nov 29; 26(54):7590-7595. Epub 2007 Jun 11.

http://www.ncbi.nlm.nih.gov/pubmed/17563749.

 

miR-10b, miR-125b, miR-145

breast cancer

down- regulated

Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri A, Musiani P, Volinia S, Nenci I, Calin GA, Querzzoli P: MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005, 65:7065–7070.

http://www.ncbi.nlm.nih.gov/pubmed/16103053.

 

miR-27a, miR-96, miR-182

 

breast cancer

up-regulated

Guttilla IK, White BA: Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells. J Biol Chem. 2009 Aug 28;284(35):23204-16.

miR-21, miR-155

breast cancer

up-regulated

Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri A, Musiani P, Volinia S, Nenci I, Calin GA, Querzzoli P: MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005, 65:7065–7070.

http://www.ncbi.nlm.nih.gov/pubmed/16103053

 

miR-21

breast cancer

up-regulated

Huang GL, Zhang XH, Guo GL, Huang KT, Yang KY, Shen X, You J, Hu XQ: Clinical significance of miR-21 expression in breast cancer: SYBR-Green I-based real-time RT-PCR study of invasive ductal carcinoma. Oncol Rep. 2009, Mar 21; (3):673-9.

http://www.ncbi.nlm.nih.gov/pubmed/19212625       

 

miR-30b, miR148a

breast cancer

up-regulated

Baffa R, Fassan M, Volinia S, O'Hara B, Liu CG, Palazzo JP, Gardiman M, Rugge M, Gomella LG, Croce CM, Rosenberg A: MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. J Pathol. 2009, 219(2):214-21.

 

http://www.ncbi.nlm.nih.gov/pubmed/19593777

 

miR-205

breast cancer

down-regulated

Baffa et al. 2009.

miR-142-5p, miR-29b, miR-30b

bladder cancer

up-regulated

Baffa et al. 2009.

miR-145, miR-143, miR-320

bladder cancer

down- regulated

Baffa et al. 2009.

miR-138, miR-125b

colon cancer

up-regulated

Baffa et al. 2009.

miR-17, miR-106a

colon cancer

down- regulated

Baffa et al. 2009.

hsa-miR-205

head and neck cancer

up-regulated

Tran N, McLean T, Zhang X, Zhao CJ, Thomson JM, O’Brien C, Rose B: MicroRNA expression profiles in head and neck cancer cell lines. Biochem Biophys Res Commun 2007, 358:12–17.

http://www.ncbi.nlm.nih.gov/pubmed/17475218.

 

miR-21, miR-221

brain cancer

up-regulated

Ciafre, S.A., Galardi, S., Mangiola, A., Ferracin, M., Liu, C.G., Sabatino, G., Negrini, M., Maira, G., Croce, C.M., Farace, and M.G: Extensive modulation of a set of microRNAs in primary glioblastomas. Biochem Biophys Res Commun 2005, 334:1351–1358.

http://www.sciencedirect.com/science/article/pii/S0006291X0501481

 

miR-9-2, miR-10b, miR-21, miR-25, miR-123, miR-125b-1, miR-125b-2,  miR-130a, miR-221

glioblastomas

up-regulated

Ciafre et al., 2005

miR-10b, miR-21, miR-26a, miR-383, miR-451, miR-486, miR-516-3p, miR-519d

glioblastomas

up-regulated

Godlewski J, Nowicki MO, Bronisz A, Williams S, Otsuki A, Nuovo G, Raychaudhury A, Newton HB, Chiocca EA, Lawler S: Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res 2008, 68:9125–9130. doi:10.1158/0008-5472.CAN-08-2629.

http://www.ncbi.nlm.nih.gov/pubmed/19010882

 

miR-7, miR-29b, miR-31, miR-101, miR-107, miR-124, miR-124-2, miR-128-1, miR-129, miR-132, miR-133a , miR-133b, miR-137

glioblastomas

down- regulated

Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG: miR-124 and miR-137 inhibit proliferation of glioblastoma multiform cells and induce differentiation of brain tumor stem cells. BMC Med 2008, 6:14. doi:10.1186/1741-7015-6-14.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443372/

 

miR-138, miR-139, miR-149, miR-153, miR-154, miR-185, miR-187, miR-203, miR-218, miR-323, miR-328, miR-330

glioblastomas

down- regulated

Gal H, Pandi G, Kanner AA, Ram Z, Lithwick-Yanai G, Amariglio N, Rechavi G, Givol D: MIR-451 and Imatinib mesylate inhibit tumor growth of glioblastoma stem cells. Biochem Biophys Res Commun 2008, 376:86–90. doi:10.1016/j.bbrc. 2008.08.107.

 

http://www.ncbi.nlm.nih.gov/pubmed/18765229

 

miR-15, miR-16

chronic lymphocytic leukemia (CLL)

down- regulated

Calin GA: Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2002, 99: 15524–15529.

http://www.ncbi.nlm.nih.gov/pubmed/12434020       

 

miR-150, miR-155           

CLL

up-regulated

Bartels CL, Tsongalis GJ: MicroRNAs: novel biomarkers for human cancer. Clin Chem 2009, Apr; 55(4):623-31. Epub 2009 Feb 26. http://www.ncbi.nlm.nih.gov/pubmed/19246618

 

miR-143, miR-145

colorectal neoplasia

down- regulated

Michael MZ, O´Connor SM, Van Holst Pellekaan NG, Young GP, James RJ: Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res 2003, 1:882-891.

http://www.ncbi.nlm.nih.gov/pubmed/14573789

 

miR-18, miR-224

hepato. Carcinoma

up- regulated

Murakami Y, Yasuda T, Saigo K, Urashima T, Toyoda H, Okanoue T, Shimotohno K: Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-timorous tissues. Oncogene 2006, 25:2537–2545.

http://www.ncbi.nlm.nih.gov/pubmed/16331254

 

miR-199, miR-195, miR-200, miR-125

hepato. Carcinoma

down- regulated

Murakami et al., 2006

miR-221, miR-222, miR-146, miR-181

papillary thyroid carcinoma

up-regulated

He H, Jazdzewski K, Li W, Liyanarachchi S, Nagi R, Volinia S, Calin GA: The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci USA 2005b, 102:19075-19080.

http://www.ncbi.nlm.nih.gov/pubmed/16365291

Pallante P, Visone R, Ferracin M, Ferraro A, Berlingieri MT, Troncone G, Chiappetta G, Liu CG, Santoro M, Negrini M: Deregulation in human thyroid papillary carcinomas. Endocr Relat Cancer 2006, 13:497–508.

http://www.ncbi.nlm.nih.gov/pubmed/16728577

 

miR-372, miR-373

testicular germ cell tumors

up-regulated

Voorhoeve PM, le Sage C, Schrier M: A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 2006, 124:1169-1181.

http://www.ncbi.nlm.nih.gov/pubmed/16564011

 

miR-31, miR-96, miR-135b, miR-183

colorectal cancer

up-regulated

Bartels and Tsongalis 2009.

miR-48, miR-135b, miR-133b

colorectal cancer

down- regulated

Bartels and Tsongalis 2009.

let-7b, let-7 g, miR-9, miR-21, miR-26a, miR-30a-3p, miR-30a-5p, miR-31, miR-96, miR-124b, miR-132, miR-135a, miR-135b, miR-141, miR-142-3p, miR-142-5p, miR-181a, miR-181b, miR-182, miR-183, miR-194, miR-200a, miR-200b, miR-200c, miR-203, miR-205, miR-215, miR-219, miR-320, miR-338, miR-372

colorectal cancer

up-regulated

Yang L, Belaguli N, Berger DH: MicroRNA and Colorectal Cancer. World J Surg 2009, 33:638–646.

 

let-7a, miR-10a, miR-15b, miR-23a, miR-25, miR-27a, miR-27b, miR-30c, miR-107, miR-124a, miR0125a, miR-125b, miR-127, miR-130a, miR-133a, miR-133b, miR-134, miR-137, miR-143, miR-145, miR-147, miR-154, miR-191, miR-199a, miR-199b, miR-214, miR-296, miR-299, miR-337, miR-339, miR-342, miR-368, miR-370, miR-582

colorectal cancer

down- regulated

Yang L, Belaguli N, Berger DH: MicroRNA and Colorectal Cancer. World J Surg 2009, 33:638–646.

miR-224, miR-18 and pre-miR-P18, miR-221

Hepatocellular cancer

up-regulated

Murakami Y, Yasuda T, Saigo K, Urashima T, Toyoda H, Okanoue T, Shimotohno K: Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-timorous tissues. Oncogene 2006, 25:2537–2545.

http://www.ncbi.nlm.nih.gov/pubmed/16331254

Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, Calin GA, Grazi GL, Giovannini C, Croce CM, Bolondi L, Negrini M: MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma.  Oncogene 2008, Sep 25; 27(43):5651-61 Epub 2008 Jun 2.

http://www.ncbi.nlm.nih.gov/pubmed/18521080

 

miR-199a, miR-199a*, miR-200a, miR-125a, miR-195, miR-125b

Hepatocellular cancer

down- regulated

Murakami et al., 2006.

Li W, Xie L, He X, Li J, Tu K, Wei L, Wu J, Guo Y, Ma X, Zhang P, Pan Z, Hu X, Zhao Y, Xie H, Jiang G, Chen T, Wang J, Zheng S, Cheng J, Wan D, Yang S, Li Y, Gu J: Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma. Int J Cancer 2008, Oct 1; 123(7):1616-22.

http://www.ncbi.nlm.nih.gov/pubmed/18649363

 


Additional reference

Stefanie S Jeffrey; Cancer biomarker profiling with microRNAs. Nature Biotechnology 26, 400 - 401 (2008)
doi:10.1038/nbt0408-400. http://www.nature.com/nbt/journal/v26/n4/full/nbt0408-400.html