Enhanced Diagnostic Tools
The majority of eukaryotic and viral messenger RNAs as well as small nuclear (snRNA) and small nucleolar RNAs (snoRNAs) involved in nuclear RNA processing are capped at the 5’end with the cap structure 5′ N7-Methylguanosine-triphosphate (7mGpppN). The cap at the 5′-terminus is required for processing and maturation of the RNA transcript in the nucleus. The methylated RNA cap is also needed to transport the message from the nucleus to the cytoplasm, ensures mRNA stability and efficient translation of the message into a protein. Synthetic RNA oligonucleotides that are modified with the 5′-N7-MeGppp cap can act as substrates and mimick cellular capped mRNAs. The synthetic 5′-N7-MeGppp oligonucleotide cap can be used for various biochemical and structural studies. Scientists have demonstrated that the cap structure can inhibit the influenza and flavivirus RNA Polymerases.
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