Enhanced Diagnostic Tools
1.5 α-melanocyte stimulating hormone analogs
α-melanocyte stimulating hormone (α-MSH) is a 13 amino acid peptide produced by pituitary gland and is mainly responsible for the regulation of skin pigmentation. Studies have shown that α-MSH receptors are distributed in more than 80% human melanoma metastases. Thus radiolabeled peptides that target these receptors are attractive probes for diagnosis of melanoma. 111In DOTA-conjugated, 18F-labeled α-MSH have been investigated in melanoma-bearing mice. 99mTc labeled dual receptor targeting peptide ligands recognizing both integrin and α-MSH receptors have been designed and they demonstrate enhanced cellular intake in melanoma both in vitro and in vivo.
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