800 Mario Court, Lewisville, TX 75057 USA Toll Free: 800.227.0627 1.972.420.8505 (Intl.) Email: info@biosyn.com           BSI also provides a wide variety of DNA and RNA Sample Purification Kits for both preparative and industrial scale. To learn more about purification of nucleic acids, Click here.                 We also provide various ways to maximize your budget, including: 5% Discount for Colleagues and Friends Referral Program.                 As always, we are available to assist you 24 hours a day, Monday to Friday. Call us today at 800.227.0627 or contact us online.         <         Both DNA and RNA 5’-triphosphates (TP’s) play an important role as substrates for several biochemical events. DNA polymerases and NTP’s are used for gene synthesis. RNA Triphosphate oligo’s are used to ligate RNA molecules to detect viral responses and to induce antiviral immunity in the enzymatic synthesis of m7G-5’-capped RNA’s. This is a necessary addition for mRNA stability prior to leaving the cell nucleus. More recently, Poeck et.al., showed that the immune response activated by triphosphate modified RNA binding to RIG-1(Retinoic acid-induced protein I) work together in synergy with gene silencing mediated by small interfering RNAs (siRNA’s). BSI provides a robust, reproducible, and scalable method for the solid-phase synthesis of these 5'-triphosphates modified oligonucleotides. Also available are their chemically modified analogues containing different 5'-terminal nucleotides, with and without internal sugar -backbone modifications. These polymers are further purified by ion-exchange HPLC and quality checked to >90% by CE, coupling efficiency profile and UV spectral data also included.               DNA and DNA Ubermer >300 bases RNA and RNA ubermer >120 bases RNA and DNA analog synthesis Bioconjugation: Oligo-Enzyme, Oligo-Antibody, Oligo-Peptide Conjugates Oligo Labeling, Immobilization           Thank you for choosing Bio-Synthesis. We always appreciate your business and input, please visit us at biosyn.com.     Bio-Synthesis - Where molecules come together TM!     Reference: Nature Medicine 14, 1256 - 1263 (2008)

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