Version History: Peptide Property Calculator
Contents:
1. PPC 3.1 (Latest)
2. PPC 3.0
3. PPC 2.5(beta)
4. PPC 2.4(beta)
5. PPC 2.0(beta)
6. PPC 1.0(beta)
- New: Added markers and tooltips for all the graphs
- Improved: The user interface of all the graphs
- Improved: The performance of the application for graphs
- New: HTML documentation of all the formulae and constant input values was provided
- Improved: Minimum length of the input sequence was changed from 5 amino acid residues to 1 amino acid residue
- Fixed: Insertion of non-standard residues to any location or position of the input sequence
- Fixed: The non functioning of the tool, if the internet options for privacy settings are set to either ?Medium High? or ?High? or ?Block all cookies? was fixed
- Updated: The representation of non-standard residues that would be attached to the input sequence was updated for better understandability
- Updated: The minimum length of the input sequence required for isoelectric point calculation was changed from 10 residues (previously) to 1 residue
- Updated: The minimum length of the input sequence required for plotting pH vs. net charge was changed from 10 residues (previously) to 1 residue
- New: Search engine optimization (SEO)
- Improved: The contents of the user guide were modified for improved comprehensibility of the features in the tool
- Updated: Option for adding multiple non-standard residues to the individual amino acid residues of the input sequence was provided
- Updated: Option for multiple internal modifications to the input sequence was provided
- New: Landing page for tool was provided
- New: User friendly UI was provided
- New: An intuitive user guide for the tool was provided
- New: Non-standard and internal modifications related details are displayed on the screen
- New: Disclaimer message was provided
- Improved: Labels were added for the various plotted graphs
- Fixed: The issue related to disappearance of hydrophobicity and hydrophilicity graphs was fixed
- Updated: The error message that is displayed when the input sequence length does not meet the specified criteria for minimum and the maximum length (5-1000 residues) was updated
- New: Input option to enter the sequence using three letter code of amino acid residues
- New: Hydrophobicity and hydrophilicity plot description
- Improved: Multiple additions of internal modifications to the input sequence
- Input option to enter the sequence by copy (Ctrl+C) and paste (Ctrl+V) method
- The maximum length of the input sequence is set to 1000 residues
- Option to perform 37 N-terminal modifications to the input sequence
- Option to perform 17 C-terminal modifications to the input sequence
- Option to perform 16 internal modifications to the input sequence
- Option to add 22 various non-standard residues to individual amino acid residues in the input sequence
- Option to add 5 various isotopes to the individual amino acid residues in the input sequence
- Option to export the graph of Hydrophobicity / Hydrophilicity
- The output is categorized into 6 broad categories with 32 various features calculated for an input sequence
- The following basic features of the input sequence are calculated :
- Chemical formula
- Molecular weight
- Extinction Co-efficient
- Sequence Composition
- Amino Acid Composition
- Isoelectric point, Net charge at pH 7, Charge, Charge attribute, Hydrophobicity at pH 2.0 and Hydrophobicity at pH 6.8 calculations are performed for the input sequence
- Option for 5 different hydrophobicity plot calculations are provided:
- Kyte-Doolittle
- Janin, Fauchere
- Manavalan
- Sweet / Eisenberg
- Option for 2 different hydrophilicity plot calculations are provided:
- Goldman, Engelberg and Steitz (GES)
- von Heijne
- Options for 4 different antigenicity plot calculations are provided:
- Parker
- Hopp-Woods
- Welling
- Protrusion Index (Thornton)
- Options for 2 different secondary structure prediction methods:
- Options for 2 different transmembrane region prediction methods:
- Surface probability and protein flexibility calculations are performed for the input sequence
|
