About Bio-Synthesis
About Bio-Synthesis

Bio-Synthesis - CRO/CMO Life Sciences Company Since 1984

Bio-Synthesis is a best-in-class contract development and manufacturing organization (CDMO) with over 40 years of experience in the synthesis of oligonucleotides, peptides, molecular biology products, and specialty APIs for biomedical organizations. We have the most advanced technology and quality control capabilities available, and we are dedicated to innovation, the highest standards of quality, and synthetic biology expertise.

Through our scale-up expertise in siRNA, ASO oligonucleotides, and biomolecule conjugation, we have evolved from a leading oligonucleotide and peptide manufacturer to a solutions provider for companies focused on therapeutic, vaccine, diagnostic, and biopharmaceutical breakthroughs.

We collaborate with some of the largest multinational biotech companies to help them move from research into clinical trials. We operate a quality system in compliance with Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients, APIs for use in Clinical Trials, and ISO 9001:2015 standards.

Products & Service

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About Us

Bio-synthesis is a biology contract manufacturer of high quality nucleic acids, peptides and other molecular biology products for the research, diagnostic and therapeutic industries. Bio-Synthesis is ISO 9001:2015 certified and follows GLP and GMP guidelines. Our solutions help advance drug discovery and bio-medical research. Founded in 1984, Bio-Synthesis is a privately held firm based in Lewisville, Texas.

Custom Peptide Synthesis

Bio-Synthesis is a provider of Custom Peptide Synthesis for the life science research community since 1984. We offer a complete range of peptide synthesis services ranging from bulk API peptides to high throughput library peptides and array peptide preparation. Custom Peptides Synthesis is performed to produce research-grade or bulk API polypeptides. We specialize in both, liquid phase and solid phase Fmoc-chemistry. Liquid Phase Peptide Synthesis is used for the synthesis of very short peptides such as dipeptides, while large-scale Solid Phase Peptide Synthesis is well suited for preparing biologically active peptides including long, difficult and hydrophobic peptides. Bio-Synthesis also provides a large number of peptide modifications as well as custom peptides for diagnostic and therapeutic applications.

Custom Oligonucleotide Synthesis

Bio-Synthesis is a provider of Custom Oligo Synthesis services. Oligonucleotides are synthesized as unmodified or modified chemical structures with defined sequences using a procedure known as Phosphoramidite solid-phase synthesis. Oligos which are synthesized using solid-phase phosphoramidite chemistry are often purified by high performance liquid chromatography (HPLC) or PAGE to achieve the desired purity. Synthetic DNA or RNA oligonucleotides obtained by solid-phase synthesis are employed in a majority of molecular biology applications such as PCR, real-time PCR, sequencing, site directed mutagenesis, single nucleotide polymorphism (SNP) assays, microarrays and various therapeutic applications.

As a pioneer in oligonucleotide synthesis, Bio-Synthesis has been pursuing the development of new oligonucleotide-based techniques that can produce compounds with superior binding affinity and chemical/biological stability. As such, Bio-Synthesis has introduced a third generation of nucleic acid analogs, Bridged Nucleic Acid (BNA).  These are RNA analogues which can be synthesized and spiked with DNA or RNA in order to modify the formation of nucleic acid helices. 

Accreditations, Associations, Trademarks & Licenses

Custom Oligonucleotides

  • 2-450 Bases in Length
  • gram to Multi-gram Scale
  • DNA, RNA, BNA, 2’OMe RNA, 2‘F-RNA, 2‘-MOE, L-DNA, L-RNA
  • Phosphodiester, Phosphorothioate
  • Methylphosphonate Linkages
  • A Wide Variety of Modified Bases
  • Hundreds of Fluorescent Dye Labels
  • Quenchers, Biotins and Other Non-fluorescent Conjugates
  • Linkers, Spacers
  • Terminal Phosphates, 5’ Terminal Caps
  • Wide Range of Real-time qPCR Probes
  • RNAi Oligonucleotides and Conjugates
  • Oligo-Enzyme, Antibody and Drug Conjugation
  • Oligo-Solid Support Attachment
  • Full Range of Final-fill, Labeling and OEM Solution
  • Contract Development
  • Traceable Manufacturing Process
  • ISO Certified Quality System

Custom Peptides

  • Length: 2 to 150+ Residues
  • Scale: g to Multi-gram, Purity >98%
  • Peptide Pooling and Library Services
  • Modifications
    • Standard Modifications:

      Phospho-peptides, Linkers, Spacers, Methylation, etc.

    • Post Translational Modifications:

      PEGylation, Cyclization, Lipopeptides, Glycosylation

    • Chromogenic / Fluorogenic Tagged:

      Biotin, Fluorescein, Dyes, Stable Isotopes, etc.

    • Unnatural & Unusual Amino Acids:

      All D-Amino Acids, Homo Amino Acids, N-methyl, Alpha, Beta, Gamma Amino Acids, Citrulline, Ornithine, Hydroxyproline, Pyroglutamic Acid

  • Long, Cyclic, Stapled Peptides
  • Peptide Biomolecule Conjugations
  • Capacity: 1,000s of peptides/order
  • Stringent Quality Control: LC-MS, ESI-MS, MALDI-TOF, HPLC, Amino Acid Analysis, Sequencing, Endotoxin and Trace Chemical Analysis etc.
  • Custom Packaging: Aliquoting, Custom Vialing, Labeling and Storage
  • Quality Guaranteed
  • Competitive Prices
  • ISO compliant, Traceable Process


  • Peptide-Oligo Conjugates
  • Antibody-Oligo Conjugates
  • Antibody-Drug (ADC)
  • Oligo-Drug Conjugates
  • Dendrimer Conjugates
  • Nano and Macroparticle Conjugates
  • Surface Modification and Immobilization
  • Dye, Quencher, Small Molecule Conjugation
  • Functional Target and Reactive Group Derivatization

BNA Technology

  • BNA Dual Labeled Probes
  • bNACLAMP PCR Blocker
  • bNACLAMP Kits Development

RNA, mRNA Transcription

    Custom RNA Transcription Synthesis (>5000 nt.) includes non-coding or capped and polyadenylated mRNA using plasmid DNA templates, PCR products, oligonucleotides or cDNA. These RNA/mRNA transcripts are ideal for diagnostic and therapeutic pre-clinical trials.

  • Assistance with design to full template preparation
  • Variety of modifications, treatments and purification options
  • From g to multi-gram scale
  • ISO compliant, fully traceable documentation system

Molecular Biology

  • Custom Gene Synthesiss
  • Plasmid DNA Preparation
  • Synthetic Templates for qPCR
  • Protein Expression
  • Molecular Diagnostic Kit Development


  • Amino Acid Analysis
  • Mass Spectrometry Analysis
  • HPLC Chromatography
  • Residual Solvent Analysis
  • Water Content Analysis
  • Endotoxin Analysis

Quality Control

  • Final Mass Determination by OD, Nmole, Weight
  • Physical Inspection of All Products
  • MALDI-TOP, ESI or LC-MS Spectrometry
  • Anion Exchange HPLC at Different pH Values
  • Reverse Phase HPLC
  • Gel Electrophoresis
  • Conductivity Measurement
  • Enzymatic Tests for Oligo-Enzyme Conjugates
  • Fluorometric Scan
  • Trace Metal and Residual Solvent Analysis
  • Endotoxin Test and Removal
  • Bioburden and More.

Ordering & Contact Information

  • Please contact us for additional information or send an email to info@biosyn.com.
  • You may also request an online quote.
  • To contact us by phone, please Call 972-420-8505 (USA) 800-227-0627 (INTL.) or Fax 972.420.0442
  • Orders may be placed using a purchase order (PO) or by credit card through our secure online ordering system.
  • When using a credit card ( creditcard ) it will be billed under "Bio-Synthesis, Inc."