Bio-Synthesis offer oligo-metal chelator  NOTA, 1,4,7-triazacyclononane-N,N',N''-triacetic acid, labeling services. NOTA has a smaller ring structyure in comparison to DOTA. It has three chelating carboxylate groups and three nitrogens with six coordination sites with metal ions. NOTA labeled oligo are often  used as organic ligands in magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT) or in application using target-specific radiopharmaceuticals.

NOTA chelator can be attached to an oligo at any position the use of different bifunctional cross linker.  Dual HPLC purification is highly recommended.

Contact us for NOTA Metal Chelator oligonucleotide labeling services or visit Chelator Bioconjugation Services for details .

Product Information


Product Name:

NOTA, 1,4,7-triazacyclononane-N,N',N''-triacetic acid


Macrocyclic Chelation, Fluorescent Metal Senor, Molecular Imaging

Modification Code:



Bio-Synthesis Inc. Oligo Structure


Dual HPLC required

Delivery Format:


Shipping Conditions:

Room Temperature

Storage Conditions:

-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.