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Largest Selection of β-Amyloid and Related Peptides

Bio-Synthesis, with over 30 years of experience in the life science communities, continues to provide you with high quality peptide products to advance your research in Alzheimer disease.

Amyloid Precursor Protein (APP) is a transmembrane protein that is predominantly expressed in the brain. Mutations and subsequent cleavages of APP by β-secretase, ϒ-secretase and caspases generated amyloid beta peptides, which have been implicated in the pathogenesis of Alzheimer's disease.1-2

Proteolytic action of β-secretase and ϒ-secretase generates amyloid β peptides of 40 or 42 residues.3-4 These peptides are susceptible to aggregate and lead to formation of amyloid plaques that characterizes Alzheimer disease.3


Biosyn beta amyloid peptide conjgates

Figure 1. Transmembrane domain of amyloid precursor protein (APP) showing the sites of cleavage by α-, β-, and ϒ-secretase. Image borrowed from Nature Reviews Neuroscience 2002, 3, 281-290 ß

Consequently, β-amyloid peptides (1-40), (1-42) and (1-28) have extensively been studied in relation to alzheimer disease.

Bio-Synthesis offers comprehensive array of human and rat beta amyloid peptide fragments for Alzherimer's disease (AD) and other neurodegenerative disease. For detail listings, click on the link below.

  • β-amyloid peptides
  • β-amyloid peptide conjugates including oligonucleotide, oligomimetic, metal chelators, dye-labeled

References

       
1 Suh Y-H., and Checler F. Pharmacol. Rev., 2002, 54, 469-525 3 Mattson MP. Nature 2004, 430, 631-639
2 Oltersdorf et al. J. Biol. Chem. 1990, 265, 4492-4497 4 Evin G. and Weidemann A. Peptides 2002, 23, 1287-1297
       
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Offer is valid until the end of October 2012 Promo ID: AP07012012

Tell us about your project and we will reply with a quote along with detailed information regarding your custom production! Enter a known colleague of yours that readily uses peptide for Alzheimer's research and receive a discount of 5% off your next order through our Colleagues and Friends Referral Program !
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