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Unnatural or unusual amino acids are not naturally encoded amino acids. These are non-proteinogenic amino acids which can occur naturally in plant or bacteria post-translationally or are chemically synthesized as pharmacological motifs. Unnatural amino acid are widely used in combinatorial libraries or as chiral building blocks. These modified amino acids often contribute to special biological activity, and are often incorporate into therapeutic peptidomimetic ligands for enhance peptide pharmacological activity and potency.
Bio-Synthesis is committed to become your peptide based drug discovery partner by providing a wide range of unnatural, non-standard amino acid peptide modifications. We routinely incorporate unnatural/unusual amino acids into peptide synthesis using D-amino acids, N-methyl amino acids, homo amino acids, alpha-methyl amino acids, beta (homo) amino acids, gamma amino acids, helix/turn stabilizing compound or backbone modification peptoides. Natural occurring unusual amino acids such as citrulline (Cit), hydroxyproline (Hyp), beta-alanine, ornithine (Orn), norleucine (Nle), 3-nitrotyrosine, pyroglutamic acid (Pyr), nitroarginine are also routinely incorporated to our peptides. If these non-standard amino acids are not available commercially, Bio-Synthesis is able to synthesize special amino acids for your specific needs.