Bridged Nucleic Acids (BNA)
Bio-Synthesis provides large scale DNA synthesis using specialized techniques capable of multi-gram DNA synthesis per lot including standard phosphodiester (PO) or phosphorothioate backbone. Large scale DNA and RNA hybrid synthesis using 2'OMe, 2'Fluoro, BNA (bridged nucleic acids) or incorporation of dye, spacers are also available. These large scale DNA oligos are often used for X-ray crystallography, NMR studies, manufacture of diagnostic kits and antisense experiments.
Our large scale DNA synthesis ranges from 50 mgs up to multi-grams, purified by HPLC and examined by analytical HPLC, PAGE, MALDI-TOF or ESI/LC/Mass spectrometry. Process development for large scale DNA synthesis under QSR manufacturing is also available.
Bio-Synthesis's large scale DNA synthesis manufacturing processes are driven by customer needs. Our scientific consultant will guide you through the transition from small batch to large scale DNA manufacturing. We provide a full range of final-fill, labeling and OEM solutions with services including but not limited to:
Prices listed are for unmodified DNA oligonucleotides between 10 and 30 bases with a PO backbone. The price includes HPLC purification and diafiltration or diafiltration only. DNA oligos with unusual sequence compositions may affect pricing. If you have an unusual sequence composition, such as a poly-G or poly A stretch, or a sequence causing secondary structure formation, our nucleic acid specialists will contact you with final pricing before processing your order.
* Prices may vary due to sequence composition
For information on pricing & ordering for large scale oligo synthesis, please supply us your project specifications in detail (e.g. foreseen application, desired type of oligo, level of purity, final yield, delivery format and level of documentation etc.), Bio-Synthesis will be able to provide an affordable price quotation based on a reasonable and cost-effective production process and provide our customer a long term stable pricing through a supply agreement.
Contact us through secure online system, write to us at email@example.com call us at 800-227-0627.
1 Large scale RNA Oligonucleotide Synthesis