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Bio-Synthesis provides large scale RNA synthesis for gene functional analysis and the development of novel therapeutic applications. Large scale RNA oligos are processed using a specialized technique and dedicated instrumentations which is capable of producing multi-gram RNA oligonucleotide per each lot. Modified or unmodified large scale RNA, chimeric oligonucleotides with mixed DNA and RNA bases, 2'-OMe-RNA, 2'-F-RNA, or other antisense RNAs are also available as custom products.

Bio-Synthesis's large scale RNA synthesis manufacturing processes are driven by customer needs. Our scientific consultant will guide you through the transition from small batch to large scale RNA manufacturing, harmonized purity specifications and analytical methods, and provide our customers with a full range of final-fill, labeling and OEM solutions. Our services include: customer-specified formulations, custom packaging, third party labeling, stability programs, functional QC, and standard operation procedure documentation.

Custom Large scale RNA Synthesis

Our large scale RNA oligo synthesis ranges from 50 mgs to multi-grams. To ensure the highest quality of RNA, all large scale RNA oligo synthesis is handled and purified in RNase free environment. All large scale RNA oligos are examined by analytical HPLC, PAGE, MALDI-TOF or ESI/LC/Mass spectrometry. Process development for large scale RNA synthesis under QSR manufacturing is also available.

Service Features:

  • 50 mgs to multi-gram quantity
  • 5-30 nt in length
  • Phosphorothioate (PS), Phosphodiester (PO) or PO/PS backbone
  • Chimeric oligo mixed 2'-OMe, 2'-F-RNA, BNA (bridged nucleic acid) or DNA
  • Wide variety of oligo modifications: dyes, spacers, linkers
  • Deliver deprotected, desalted or purified
  • Sterilization/filtration, endotoxin testing, Na+ salt exchange, normalization and aliquoting is an option
  • Q.C. by HPLC, PAGE, MALDI-TOF or ESI/LC/Mass spectrometry
  • Long-term pricing stability available through supply agreement

Prices listed are an example of unmodified RNA oligonucleotides between 10 and 30 bases with a PO backbone. The price includes HPLC purification and diafiltration in an RNAase free environment. RNA oligos with unusual sequence compositions may affect pricing. If you have an unusual sequence composition, such as a poly-G or poly A stretch, or a sequence causing secondary structure formation, our nucleic acid specialists will contact you with final pricing before processing your order.

RNA HPLC Purified*
50 mgs $ 2,500
100 mgs $ 3,500
250 mgs $ 6,000
500 mgs $ 10,500
1000 mgs $ 14,500
>1000 mgs Inquire

* Prices may vary due to sequence composition

Quotation and Ordering

For information on pricing & ordering for large scale oligo synthesis, please provide your project specifications in detail (e.g. foreseen application, desired type of oligo, level of purity, final yield, delivery format and level of documentation etc.), Bio-Synthesis will be able to provide an affordable price quotation based on a reasonable and cost-effective production process and provide our customer a long term stable pricing through a supply agreement.

Contact us through secure online system, write to us at call us at 800-227-0627.

Related product for large Scale oligonucleotide Sythesis

* Large scale DNA Oligonucleotide Synthesis

Ordering & Contact Information

  • Please contact us for additional information or send an email to
  • You may also request an online quote.
  • To contact us by phone, please call 1-972-420-8505 or Fax at 1-972-420-0442
  • Orders may be placed using a purchase order (PO) or by credit card through our secure online ordering system.
  • When using a credit card ( creditcard ) it will be billed under "Bio-Synthesis, Inc."