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Modified oligonucleotides (modified DNA and modified RNA) have been helpful in understanding
mechanistic and stereochemical aspects of numerous biochemical reactions and processes.
Bio-Synthesis provides a full spectrum of high quality custom oligo modification
services by direct solid-phase chemical synthesis or enzyme-assisted approaches to
obtain artificially modified oligonucleotides containing backbone, base, sugar and internucleotidic
Bio-Synthesis's integrated FlexOligo Synthesis platform results in significant cost
savings by increasing chemical coupling efficiency and allows for significant scale-up
production in a short time. We specialize in complex oligonucleotide modifications using phosphodiester backbone, purine and pyrimidine heterocyclic bases, and
sugar modified nucleotides such as our patented 3rd generation Bridged Nucleic
Acids. These modified oligos have been used as structural and
mechanistic probes in diverse areas of diagnostic and therapeutic applications.
If you are unable to find your desired product please contact us for assistance or send an email to firstname.lastname@example.org
You may retieve a modified oligonucleotide by performing a product search or by clicking the tabs below to view an alphabetical list all the modified oligonucleotides.