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Modified oligonucleotides (modified DNA and RNA) are essential tools for understanding and manipulating biological processes. Bio-Synthesis Inc. is a leading provider of custom oligonucleotide modifications services, offering a wide range of modifications to meet your specific needs. oligonucleotide modifications can transform ordinary oligonucleotides into potent antisense oligonucleotides (ASOs), splice-switching oligonucleotides (SSOs), small interfering RNA (siRNA), and RNA aptamers. Unleash the full potential of your research and explore the possibilities with oligonucleotide modifications.

Our integrated FlexOligo Synthesis platform results in significant cost savings and allows for rapid scale-up production. We specialize in complex oligonucleotide modifications, including backbone modifications, base modifications, and fluorescent dye labeling. Our modified oligonucleotides are synthesized to the highest quality standards and are used in a variety of research and diagnostic applications.

Why choose Bio-Synthesis Inc. for your oligonucleotide modifications needs?

  • Wide range of chimeric and fully modified modifications including:
    • Backbone modifications: phosphorothioate linkages, methylphosphonate linkages, phosphoryl guanidium linkages, locked nucleic acids (LNAs), thio morpholino oligonucleotides (TMOs) and peptide nucleic acids (PNAs)
    • Base modifications: 2'-O-methyl, 2'-O-fluoro, 2’ MOE and other base modifications to improve nuclease stability and affinity
    • Fluorescent dye labeling: a wide range of fluorescent dyes available to meet your specific detection needs
    • Bioconjugations: Lipid-oligo conjugation and Peptide-oligo conjugation
  • Custom synthesis services: we can synthesize modified oligonucleotides of any length or sequence to meet your specific needs
  • High quality standards at competitive pricing
  • Rapid turnaround

If you are unable to find your desired product please contact us for assistance or send an email to info@biosyn.com

Discover the power of oligonucleotide modifications!

These incredible molecular tweaks can transform ordinary oligonucleotides into potent antisense oligonucleotides (ASOs), splice-switching oligonucleotides (SSOs), small interfering RNA (siRNA), and RNA aptamers. Unleash the full potential of your research and explore the possibilities with oligonucleotide modifications.

Therapeutic oligonucleotides are short DNA/RNA-like strands that utilize gene-silencing techniques for various applications. These short DNA/RNA oligonucleotides can regulate gene expression by binding to target mRNA sequences via Watson-Crick base pairing through hydrogen bonds. Their specific binding ability to the complementary mRNA makes them a potential tool for drug development, as they can selectively target undruggable human and viral genomes. Antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) are the two most used gene silencing strategies.

Antisense oligonucleotides (ASO), function as a single strand. Their mechanism of action involves either promoting RNA degradation through the RNase H enzyme or without degradation through splice modulation and translation arrest. Targeting specific codons, splicing modulators prevent splicing during translation through exon skipping and inclusion. Pre-mRNA splicing machinery binds to ASOs to skip mutant exons, repair RNA frame, and produce functional proteins in exon skipping. ASOs attach to pre-mRNA to prevent splicing machinery from accessing transcript sites, resulting in exon exclusion. Splice-modulating oligonucleotides can treat disorders with splicing defects or disease-causing mutations in target exons. Steric blocker oligonucleotides bind to target RNA and inhibit ribosomal activity, causing translational arrest through steric hindrance. Gene expression inhibitors cause selective breakdown of DNA-RNA heteroduplexes via RNase H enzyme, releasing mRNA and leaving DNA intact, reducing target gene translation.

Small interfering RNAs, commonly known as siRNAs, are double-stranded oligonucleotides consisting of a guide strand and a passenger strand. RNA interference (RNAi) is a biological process in which double-stranded small interfering RNAs (siRNA) induce mRNA degradation and suppress target gene expression. During RNA interference (RNAi), a small RNA duplex combines with the RNA-induced silencing complex (RISC). The passenger strand is discarded, and the remaining guide strand works with RISC to bind complementary RNA sequences.

Most widely used modifications of oligonucleotides

You may retieve a modified oligonucleotide by performing a product search or by clicking the tabs below to view an alphabetical list all the modified oligonucleotides.

If you are unable to find your desired product please contact us for assistance or send an email to info@biosyn.com

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Welcome To Biosynthesis - Oligonucleotide Modification Products
>Backbone Modified Oligos
>Cross-Link Base Modified Oligos
>Dendrimer Branch Oligo Synthesis
>Enzyme Oligo Labeling Services
>Inverted Base Modified Oligos
>Janelia Fluor Dyes
>Phosphorylated Oligos
>Photocleavable Modified Oligonucleotide Synthesis
>Spacer Modified Oligonucleotide Synthesis
>Terminal Cap
2' Deoxynebularine, dN Oligonucleotide Modification
2' Fluoro RNA Modification
2' O-Methyl RNA (2' Me) Synthesis
2' Phosphate Oligonucleotide Modification
2' Thiophosphate Oligonucleotide Modification
2',2'-Difluorodeoxycytidine (Gemcitabine) dFdC Modified Oligo
2,2'-Dipicolylamine
2',3'-Dideoxyadenosine, ddA Oligonucleotide Modification
2',3'-Dideoxycytidine, ddC Oligonucleotide Modification
2',3'-Dideoxyguanosine, ddG Oligonucleotide Modification
2',3'-Dideoxythymidine, ddT Oligonucleotide Modification
2,6-Diaminopurine-2'-deoxyriboside (DAPdR) Oligonucleotide Modification
2,6-Diaminopurine-2'-O-methylriboside Oligonucleotide Modification
2,6-Diaminopurine-riboside Oligonucleotide Modification
2',7'-Dichloro- fluorescein
2-Aminopurine-2'-deoxyriboside Oligonucleotide Modification
2-Aminopurine-2'-O-methylriboside Oligonucleotie Modification
2-Aminopurine-Ribose Oligonucleotide Modification
2'-Deoxycytidine-5-C6 Amino Linker (Amino C6-dC)
2'-Deoxyguanosine-8-C6 Amino Linker (2'-dG-C6-NH2)
2'-Deoxyinosine Oligonucleotide Modificaiton
2'-Deoxyisoguanosine
2'-Deoxypseudouridine Oligonucleotide Modification
2'-Deoxyuridine
2'-F-arabinonucleic acid (2'-F-ANA) Oligonucleotides
2-Fluoro deoxy Inosine dl (convertible dG) Oligonucleotide Modification
2'-MOE, 2-MethoxyEthoxy, RNA Modification
2'-O-Methylinosine, 2'-OMe-I Oligonucleotide Modification
2-Thiothymidine Oligonucleotide Modification
3' Carboxy Linker Oligonucleotide Modification
3' Phosphate Oligonucleotide Modificaiton
3' Thiol C3 Linkers
3' Thiophosphate Oligonucleotide Modification
3' Uaq Cap
3'-3' Reverse Linked Oligonucleotide
3-Cyano-7-Ethoxycoumarin Oligo Labeling
3-cyanovinylcarbazole nucleoside CNVK Ultrafast Photo Cross-Linker
3-deaza-2'-deoxyadenosine, 3-deaza-dA
3-Deaza-5-Aza-2'-O-methylcytidine Oligonucleotide Modification
3'-Deoxyadenosine, Cordycepin,2'-5' Linked Oligonucleotide Modification
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