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The production of large scale (multi-gram) peptides is accomplished using solid-phase or liquid-phase synthesis. Solid-phase synthesis offers the benefits of shorter process development and manufacturing time with greater cost efficiency at small to medium-scale production, but can also remain competitive for larger-scale processes and for producing longer sequences and more complex peptides with elaborate side chains. Solution-phase synthesis on the other hand may be advantageous as product quantities increase.
The key is to optimize process development and achieve highly efficient conversion at every amino acid coupling to produce a high-purity crude synthetic custom peptide and minimize the demands on downstream processing. While decision on which synthesis route is a case-by-case basis, Bio-Synthesis offers cost analysis, project review, R & D process optimization and detailed qualification reports on all CMO large scale peptide production.
Peptide applications play an important role in biochemistry, molecular biology, immunology and medicine. In the human body, most if not all biological/physiological processes are regulated by various forms of molecular recognition. Most of these processes involve initiation or inhibition trough protein-protein interaction. As we know, peptides and proteins due to the vast number of conformational possibilities are ideal to carry out such complex control functions. Synthetic peptides have been widely used for the following purposes:
The last 40 years have seen an enormous growth in the methodologies available to obtain peptide and protein molecules. Through recombinant methods, most labs can now assemble genes, subclone them into expression vectors and obtain a wide range of endogenous proteins. Likewise the pioneering work of Bruce Merrifield, makes it possible to obtain large scale with multi-kilo amounts of a number of biologically active peptides.
Bio-Synthesis has been producing synthetic peptides for over 28 years. Our expertise in custom synthetic polypeptide manufacturing allows us to produce the high-quality, large-scale, and GMP peptides with the highest success rate with long standing records. We have delivered more than 100,000 peptides to customers worldwide, including very hydrophobic polypeptides, peptides with multiple disulfide bonds, multi-phosph0rylated peptides and extremely long peptides. Our largest scale non-GMP ever delivered was 5 kilograms of peptides on a single order and has the capacity of 10,000 peptides per month. Our capacity of GMP peptide is 10 kilograms.
Contact us for more information on large scale peptide production.
All peptides undergo stringent quality control. Peptide delivery consists of lyophilized peptides of the required sequence, purity, and quantity and associated QC reports.