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Bio-Synthesis is a provider of Custom DNA Synthesis services tailored to our customers specifications. Our DNA Oligo synthesis scale ranges simple to complex, multi-gram scale up to 400 bases. We offer an extensive range of DNA oligonucleotide modifications including DNA backbone modifications, modified bases and fluorescent dye labeling. These modified oligonucleotides conform to the highest quality specifications for research, diagnostics, OEM and therapeutics.
DNA oligos are deprotected and desalted using SEC chromatography to remove impurities causes by trace molecules as part of our HPLC or PAGE purification process. Oligos are quantified twice by UV spectrophotometry to provide an accurate measure of OD yield. As part of our quality control process, DNA oligos are characterized by MALDI, or ESI Mass spectrophotometry and their purity is checked by analytical HPLC/PAGE.
Phosphodiester (PO) $10 Minimum (25 to 50 nmole) $20 Minimum (100 to 250 nmole)
$60 Minimum (1 to 15 µmole)
Click here for recommended purification and applications
Click here for information regarding methods of purification
We offer several scales of custom unmodified DNA synthesis at very competitive prices. From small scale (custom DNA for research) to large production of ASR and GMP DNA oligomers. More Information...
Long DNA, as an internal control template with or without certain SNP's is used in amplification reactions such as Real-Time PCR and qPCR. More Information...
High-throughput synthetic DNA can be provided in 96 or 384 well plates. We can customize the plate type required for your system. Options for oligos in solution include equimolar concentration, forward and reverse primer in the same well, dilution in buffer or water, and equal or variable volume. Options for lyophilized oligos in plates include equal nmole amounts or µg amount. More Information...
We provide thousand of custom DNA modifications such as DNA methylation, DNA base modification, backbone modification, and many others. More Information...
We offer a wide variety of fluorescent reporters and quenchers including common dye modifiers such as 6-FAM, HEX and TET, as well as a full range of exotic modifications. More Information...
Antisense oligos are powerful tools to halt biological events such as transcription, translation or splicing. We offer hybrid synthesis of RNA-DNA duplexes with mixed backbone linkages. More Information...
Synthesis of chimeric DNA, chimeric DNA/RNA, chimeric DNA-peptide conjugates provides companies and researchers with powerful tools for research and pharmaceutical applications. More Information...
At Bio-Synthesis we have developed methods for synthesizing complex and long oligos. Below, you will find a custom oligo synthesis case study representing our capability to synthesize long DNA & RNA, both chemically or enzymatically at our synthetic biology laboratory.
Complex synthetic oligos are purified by gel electrophoresis and analyzed by analytical gel electrophoresis and mass spectrometry.
Sequence: GCA GCT TGG TTA CCA GAA CGA TAA CAA TAG TTT GCA GCT TGG TTA CCA GAA CGA TAA CAA TAG TTT GCA GCT TGG TTA CCA GAA CGA TAA CAA TAG TTT GGC AGC TTG GTT ACC AGA ACG ATA ACA ATA GTT TGC AGC TTG GTT ACC AGA ACG ATA ACA ATA GTT TGC AGC TTG GTT ACC AGA ACG ATA A
QC: LC/MS, ESI and PAGE Gel analysis