40+ years of excellence in custom synthesis and bioconjugation services.
Calculators, design tools, and educational content to support your research.
Explore 3,000+ DNA/RNA modifications with expert design support, rapid quoting, and custom solutions tailored to your assay, workflow, or therapeutic program needs.
Bio-Synthesis offers one of the industry's broadest portfolios of DNA & RNA oligonucleotide modifications supporting research, diagnostics, sequencing, CRISPR, molecular detection, and therapeutic development. Our modification reference guide helps researchers identify the right chemistry, label, linker, or conjugation strategy for highly specific applications.
With over 3,000 modification options and growing, Bio-Synthesis delivers high-quality, custom-modified oligonucleotides backed by expert technical support. If the modification you need is not listed, please contact us—our team is ready to develop a custom solution tailored to your specific research requirements.
Core nucleotide chemistry, analogs, stability improvements, and structural modification options.
Placement-specific modification options for 5′, 3′, internal, and RNA capping designs.
Functional handles for bioconjugation, delivery, immobilization, and controlled-release workflows.
Labeling and signal-control options for qPCR, imaging, hybridization assays, and analytical workflows.
Bio-Synthesis supports a wide range of modified oligonucleotides for molecular biology, diagnostics, qPCR, CRISPR, sequencing, therapeutic research, and advanced analytical workflows. Available options include fluorescent oligos, affinity tags, quencher-modified probes, RNA modifications, backbone modification chemistries, and oligo conjugation handles.
Researchers can choose from modification technologies such as phosphorothioate backbone modifications, linker chemistries, biotin and other affinity labels, lipid conjugates, specialty bases, redox tags, and functional groups designed for immobilization, delivery, detection, or downstream bioconjugation.
Explore supporting oligo services for modified oligo programs, from conjugation to purification and QC.
Include sequence length, modification type, synthesis scale, purification target, delivery format, and QC requirements.
Trusted by biotech leaders worldwide for over 45 years of delivering high-quality, fast, and scalable synthetic biology solutions.