LNP Encapsulation Services
Bio-Synthesis offers lipid nanoparticle (LNP) formulation technology for efficient and targeted delivery of nucleic acids, mRNA, siRNA, and gene therapies. Our custom LNP formulation services enable stable, biocompatible, and scalable delivery platforms for modern therapeutics.
Introduction:
Lipid nanoparticles (LNPs) have revolutionized the delivery of modern therapeutic agents, especially in mRNA vaccines, gene editing, and RNA therapeutics. With proven clinical success, LNPs offer superior delivery efficiency, protection of payloads, and targeted biodistribution.
Key Benefits of LNP Delivery:
- High encapsulation efficiency for nucleic acids
- Protection from degradation in circulation
- Targeted delivery to specific tissues
- Reduced immunogenicity and toxicity
- Scalable for clinical and commercial production
Applications:
- mRNA vaccines (e.g., COVID-19 vaccines)
- siRNA and RNAi therapeutics
- CRISPR gene editing systems
- Antisense oligonucleotides
- Protein and peptide therapeutics
LNP Composition:
Bio-Synthesis formulates LNPs using optimized combinations of:
- Ionizable lipids: Enable endosomal escape
- Structural lipids (e.g., DSPC): Stabilize lipid bilayer
- Cholesterol: Improve membrane integrity
- PEG-lipids: Enhance circulation time and stability
Manufacturing Process:
We use microfluidic mixing for reproducible, scalable LNP assembly, ensuring uniform size distribution and optimal encapsulation.
- Particle sizes: 60-150 nm
- High encapsulation efficiency (>90%)
- Custom payload loading (mRNA, siRNA, DNA, proteins)
Why Choose Bio-Synthesis?
- Decades of experience in oligonucleotide and nanoparticle synthesis
- Custom formulation to meet your specific needs
- Analytical characterization and QC support
- Small-scale R&D to full-scale cGMP manufacturing
Get Started with LNP Services
Contact our technical team to discuss your project needs. We offer consultation, formulation optimization, and production services for from start to finish.