Custom LNP encapsulation support for siRNA, ASO, mRNA, and oligonucleotide delivery programs.
Lipid nanoparticles (LNPs) are clinically validated delivery systems for siRNA, mRNA, and therapeutic oligonucleotides.
Bio-Synthesis provides end-to-end custom lipid nanoparticle formulation and microfluidic LNP encapsulation services to support reproducible particle size, controlled PDI, high encapsulation efficiency, and scalable oligonucleotide delivery workflows for siRNA, ASO, and mRNA programs.
Custom LNP encapsulation workflows built around your payload, target size, buffer, and QC requirements.
Concept: oligonucleotide payload enters and is retained within the lipid nanoparticle.
FRR/TFR control for consistent particle size and PDI.
Custom lipid ratios, buffers, and nucleic acid chemistries.
TFF or dialysis into PBS or your preferred formulation buffer.
Batch records, COA, QC reports, and traceability support.
Small RNA LNP support
LNA / cEt compatible review
Encapsulation and stability support
DLS, EE%, zeta, LAL
The workflow is organized around formulation control, buffer exchange, sterile filtration or polishing, and release analytics.
Process parameters are tuned around payload type, target particle size/PDI, encapsulation efficiency, lipid composition, buffer exchange, sterile filtration, and QC release criteria.
Specifications below are examples. Final release criteria should be set by modality, dose, formulation, and regulatory context.
Discuss lipid composition, FRR/TFR, target size/PDI, N:P ratio, buffer exchange, sterile filtration, and stability planning.
Include payload, target size/PDI, EE% goal, final buffer, scale, QC panel, storage condition, and documentation needs.
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