SMCC-maleimide (succinimidyl 4-[N-maleimidomethyl] cyclohexane-1-carboxylate) is a heterobifunctional cross-linker that can be covalently labeled at any position within an oligonucleotide that contains a primary amine. The succinimidyl ester group of SMCC-maleimide reacts with the primary amine to form a stable amide bond, which serves as a connector or linker to attach the oligonucleotide to other thiol-containing molecules, such as peptides or proteins. SMCC-maleimide oligonucleotide conjugates are a versatile tool in bioconjugation chemistry.

SMCC-maleimide is modified post-synthetically, meaning that the oligonucleotide must first be synthesized and then modified with SMCC-maleimide. The precursor amino-modified oligonucleotide is recommended to be purified by HPLC prior to labeling.

Contact Bio-Synthesis to learn more about SMCC-maleimide oligonucleotide synthesis and modification.

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Cross Linking

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Room Temperature

Storage Conditions:

-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at 20°C) in a nuclease-free environment should be stable for years.

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