New nucleic acid diagnostic tool with enhanced hybridization and quantification power.
Shivarov et al. published their work using BNA-NC probes allowed for the quantitative and sensitive detection of different mutant alleles. This rapid, easy and reliable diagnostic method is expected to allow the detection of myeloid malignancies. View Video
Welcome to the Peptide Library Screening Tool presented by Bio-Synthesis
Bio-Synthesis has implemented Peptide Library Tools to its rapid high-throughput parallel peptide synthesis platform. These libraries can be used to screen highly active compounds such as antigenic peptides, receptor ligands, antimicrobial compounds and enzyme inhibitors.
These seven powerful peptide library generation tools provide client with the ability to generate large numbers of screening peptide which involves epitope mapping, sequence optimization, and sequence stabilization. Epitope mapping requires the construction of overlapping peptide libraries, which can be customized by adjusting the fragment length and offset number for the optimum balance between low costs and high data value. In addition to overlapping peptide libraries, Bio-Synthesis offer seven additional systematic peptide library screening service tools featuring different strategies for sequence optimization.
Overlapping Peptide Library: The generation of peptide library by breaking the original protein or peptide into many equal-length overlapping fragment and it is used for linear, continuous epitope mapping and T-cell epitope determination.
Alanine Peptide Scanning Library: The generation of peptide library in which alanine (Ala, A) is systematically substituted into each of the amino acids which can be used to identify epitope activity.
Positional Peptide Library: A selected position in a peptide sequence is systematically replaced with different amino acid to show the effect on the substitute amino acid at certain position.
Truncation Pepitde Library: The truncation library is been used to predict the minimum amino acid length required for optimum epitope activity.
Random Peptide Library: It's constructed by substituting selected positions on the original peptide randomly and simultaneously with all other natural amino acids in a shot gun approach with a purpose to elucidate potential alternatives for enhanced peptide activity.
Scramble Peptide Library: Scramble Library is constructed by carrying out permutation on the original peptide's sequence. It has the potential to give all possible alternatives and offers and represents the highest degree of variability for
T-cell Truncated Peptide Libraries: Allow the testing of all possible T-cell epitopes across a protein of interest.