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Definition

Cholecystokinin (CCK), also called pancreozymin, is a peptide hormone in the small intestine that constitutes the classical gut hormone triad together with gastrin and secretin1. CCK is secreted into the blood following ingestion of a meal and plays a critical role in the ingestion, absorption, intestinal motility, satiety signaling, inhibition of gastric acid secretion and digestion of food1.

 

Discovery

CCK was discovered in 1928 because of its ability to induce gallbladder contraction2.

 

Classification

CCK is a neuropeptide.  It is a family of hormones identified by the number of amino acids, for eg: CCK58 and CCK331. 

 

Structural Characteristics

Prepro-CCK is a115 amino acid peptide that is first cleaved to pro-CCK which in turn results in CCK58, the major processed form of CCK3.  CCK58 assumes a helix-turn-helix configuration3.

 

Mode of action

CCK binds to CCK receptors on the cell membrane that when activated increase the turnover of phosphatidyl inositol which results in the release of intracellular calcium4.  The calcium released causes increased enzyme secretion either directly or through activation of protein kinase C4.

 

Functions

CCK induces the gall bladder to contract and eject bile into the intestine5. It stimulates the acinar cells of the pancreas to release water and ions and stimulates the secretion of a juice rich in pancreatic digestive enzymes5. It is known to induce growth of the exocrine pancreas and to stimulate insulin secretion5. CCK is the most abundant neuropeptide in the human brain where it induces panic attacks that are antagonized by a central cholecystokinin receptor antagonist6. ProCCK is expressed in certain neuroendocrine tumors and sarcomas, and the secretion of CCK is impaired in celiac disease and bulimia nervosa7.

 

 

References

 

1.     Fink H, Rex A, Voits M, Voigt JP (1998). Major biological actions of CCK--a critical evaluation of research findings. Exp Brain Res., 123 (1-2), 77–83.

2.     Hunt, J. N. (1948). A method for estimating peptic activity in gastric contents. Biochem. J., 42, 104-109.

3.     Book: Neuropeptides By Fleur L. Strand, 387-389.

4.     Dufresne M, Seva C, Fourmy D (2006). Cholecystokinin and gastrin receptors. Physiol. Rev., 86 (3), 805–47.

5.     Chandra R, Liddle RA (2007). Cholecystokinin. Curr Opin Endocrinol Diabetes Obes., 14(1), 63-7.

6.     Rehfeld JF, Friis-Hansen L, Goetze JP, Hansen TV (2007). The biology of cholecystokinin and gastrin peptides. Curr Top Med Chem, 7(12), 1154-65.

7.     Rehfeld JF (2004). Clinical endocrinology and metabolism. Cholecystokinin. Best Pract Res Clin Endocrinol Metab., 18(4), 569-86.

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If you are unable to find your desired product please contact us for assistance or send an email to info@biosyn.com

 
Product Name Catalog # Unit Price/Unit 
Caerulein
Pyr-QD-Y(SO3H)-TGWMDF-CONH2
10911-01 1 mg $193 cart inquire
Cholecystokinin (10 - 20)
IKNLQSLDPSH
10908-01 1 mg $170 cart inquire
Cholecystokinin (1 - 21)
KAPSGRVSMIKNLQSLDPSHR
10907-01 1 mg $350 cart inquire
Cholecystokinin (26 - 33) CCK8
DYMGWMDF-CONH2
10905-01 1 mg $120 cart inquire
Cholecystokinin (26 - 33), CCK Octapeptide, sulfated
D-Y(SO3H)-MGWMDF-CONH2
10906-01 1 mg $315 cart inquire
Cholecystokinin (26 - 33), free acid
DYMGWMDF
10910-01 1 mg $230 cart inquire
Cholecystokinin, CCK (27 - 33), CCK7
YMGWMDF-CONH2
10913-01 1 mg $185 cart inquire
Cholecystokinin Flanking Peptide, non - sulfated
SAEEYEYPS
10912-01 1 mg $225 cart inquire
Prepro CCK fragment, V - 9 - M
VPVEAVDPM
10914-01 1 mg $195 cart inquire
[Thr28, Nle31] - Cholecystokinin (25 - 33), sulfate
RD-Y(SO3H)-TGW-Nle-DF-CONH2
10909-01 1 mg $350 cart inquire

Biosynthesis Inc.