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DNA Modifications
Molecular Probe Dye Oligo Labeling

Other Dyes from Molecular Probes
Molecular Probes has developed and patented a series of additional fluorescent dyes. Their unique characteristics make them particularly useful in applications such as DNA typing.

This compound requires amino- or thiol- linker with a 6-Carbon spacer arm or by substituting any thymidine with 5-C6-Amino-2'-deoxythymidine for internal labeling, a double HPLC purification is required.

Contact your Account Representative for pricing on other dyes dye labeled oligonucleotides. For additional information, please Contact us.

Price/labeling, purification and synthesis is an additional charge

Dyes Scales Label position
5' Int 3'
Cascade BlueTM 250 nmol $225 $325 $225
1.0 µmol $275 $375 $275
2'-OMeMarina Blue® 250 nmol $175 $275 $175
1.0 µmol $225 $325 $225
Pacific Blue® 250 nmol $175 $275 $175
1.0 µmol $225 $320 $225
Texas Red® Mix-Isomer 250 nmol $200 $300 $225
1.0 µmol $250 $350 $390
Texas Red® Single-Isomer 250 nmol $225 $325 $225
1.0 µmol $250 $350 $250


A wide variety of modifications can be incorporated into an oligonucleotide at the time of synthesis, using aspecialized phosphoramidite chemistries for labeling. However, certain modifications require the use of post-synthetic conjugation strategies in which a primary amine modified oligonucleotide is covalently attached to a dye via NHS ester chemistry. Other cross-linking chemistries are also available depending on particular project specifications. Single HPLC purification is recommended when using phosphoramidite oligo chemistry, otherwise dual HPLC is required for post-synthetic labeling.

Minimum Guarantee Purified Yield

Due to the chemistry of many modifications, yield will be approximately 40 - 60 % less than a standard oligo. Please see our yield chart for details.

Quality Controls

Every oligo synthesized is strictly controlled for quality by using either MALDI-TOF mass spectrometry or polyacrylamide gel electrophoresis (PAGE) analysis. Final yields are determined using UV absorbance at OD260 In addition, we perform QC methods tailored to specific modifications, such as OD ratio measurement where appropriate.

For additional information, please Contact us.

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