Bio-Synthesis offer 5-Carboxy-dC modified DNA base oligo synthesis. This compound was first synthesized in 2007 by Sumino et al1 as an anion carrier that, when incorporate 5-Carboxy-dC into an oligos, it increases the Tm ~2 °C per insertion in a duplex. However, in triplex forming oligos, when used in the third strand, 5-Carboxy-dC insertions have a destabilizing effect, lowering the Tm ~4-5° C1. Recent study have shown, 5-carboxy-dC has potential role as an intermediate in a putative (active) oxidative demethylation pathway for conversion of 5-Me-dC to dC. Demethylation of 5-Me-dC is necessary for epigenetic control of gene expression in the cell, and plays a key role in cellular reprogramming, embryogenesis, establishment of maternal and paternal methylation patterns in the genome2, and also in certain autoimmune disorders and cancer3. Contact us for more information regarding 5-carboxy dC Oligo Synthesis Services.
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-20°C To -70°C Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.
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