6-Thio-Guanosine (6-thio-G) is an photoreactive RNA base has been often use in ribozyme and siRNA research , as well as RNA-protein interactions.  In one of the study has shown RNA can isolated by treatment of cell s in the culture with 6-thiogunosine or 4-thiouridine followed by affinity chromatography on mercurated cellulose columns. 4-Thiouridine (4-thio U) and 6-thioguanosine (6-thio G) are specifically used for identification of components of RNA-binding by its ability to site-direct cross link to the center of ribosome. This photo-reactive base can form the so-called zero-length cross-linking. A sigle 6-thio G base in an RNA molecule does not change its spatial structure when forming RNA-RNA cross-link. this modification allows one to idetnify direct contacts between nucleotides of rRNA and RNA  ligands.

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Product Information


Product Name:

6-Thio-Guanosine, 6-Thio G RNA Oligonucleotide Modification


RNA Minor Base

Modification Code:



Bio-Synthesis Inc. Oligo Structure



Delivery Format:


Shipping Conditions:

Room Temperature

Storage Conditions:

-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.