7-Deaza-Adenosine, 7-Deaza-A RNA Modification
7-Deaza-Adenosine can be modified any where within the oligonucleotide. This modified bass is lacking nitrogen at the 7-position, which is replaced by carbon. The N7 position in adenosine takes part in non-Watson and Crick hydrogen bonding, which may be relevant to RNA folding and subsequent activity. This Adenosine analogue is also known as Tubercidin. 8-Aza-7-deaza-Adenosine is an isomer of Adenosine with virtually identical electron density. Again, the N7 nitrogen is not available for hydrogen bonding. Nebularine or Purine Nucleoside can be viewed as an Adenosine derivative that is lacking the exocyclic amino group. This molecule allows researchers to determine the relevance of the exocyclic amine of Adenosine to RNA structure and function. If functionality is lost after substitution of Nebularine for Adenosine, then hydrogen bonding involving the exocyclic amine can be inferred, while retention of functionality infers the opposite.
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Product Information
7-Deaza-Adenosine, 7-Deaza-A RNA Modification
RNA Minor Base; Ribonucleoside Modified Bases
-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.
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